摘要
目的探讨肾集合管癌(collecing duct carcinoma,CDC)的临床病理特点、诊断及鉴别诊断。方法对4例CDC进行临床病理学观察及免疫组化标记,并复习相关文献。结果肿瘤位于肾髓质内,镜下为管状、乳头状结构,肿瘤细胞呈靴钉样,伴间质纤维化及炎症细胞反应,肿瘤旁集合管上皮细胞可见异型增生;免疫表型示肿瘤细胞CKpan、CKL、CKH及CK7均(+),vimentin部分(+)(2/4),CK20、CD10、RCC均(-)。结论 CDC是一种高度恶性的肾上皮性肿瘤,临床罕见,易误诊,免疫组化有助于诊断及鉴别诊断。
Purpose To study the clinicopathological features of collecting duct carcinoma（CDC） and the key points of its diagnosis and differential diagnosis.Methods The clinicopathological and immunohistochemical staining in 4 cases of CDC were presented with review of relevant literature.Results Tumors were located in the medullary zone of the kidney,and microscopically,the tumor showed prominent tubular and tubular-papillary structures with desmoplastic stromal reaction.Simultaneously,the tubular epithelial atypical hyperplasia was observed in the adjacent renal medullary.Immunohistochemically,the tumor cells were positive for CKpan,CKL,CKH,CK7 and vimentin（2/4）,but negative for CK20,CD10 and RCC.Conclusions Collecting duct carcinoma of kidney is a rare,high grade tumor and it is easily misdiagnosed.Immunohistochemistry plays an important role in its diagnosis and differential diagnosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2012年第4期419-421,428,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
肾肿瘤
集合管癌
诊断
鉴别诊断
kidney neoplasms
collecting duct carcinoma
diagnosis
differential diagnosis
