摘要
目的:探讨肾嫌色细胞癌的临床病理特点、免疫学表型及预后。方法:对23例肾嫌色细胞癌进行光镜观察、免疫组化研究及随访,其中2例进行电镜观察。结果:23例肾嫌色细胞癌中瘤细胞呈大圆形或多角形,膜较厚,胞质半透明细网状,可见核沟及核异型;部分细胞胞质嗜酸,可见明显透明的核周空晕。免疫组化表达率分别为:EMA和Ksp-cadherin全部(+),CD10(+)(11/23),vimentin全部(-),CK7(+)(17/23),CD117(+)(22/23)。23例中2例伴有肉瘤样癌成分,21例存活,2例死亡。结论:肾嫌色细胞癌是一种少见的来源于集合管上皮细胞恶性肿瘤,临床预后好,伴肉瘤样癌成分者预后较差。
Objective：To study the clinicopathological features, differential diagnosis and prognosis of chromophobe cell renal carcinoma. Methods： The microscopic and immunohistochcmical features were examined in 23 cases of chromophobe cell renal carcinoma and followed up, 3 of them by electron microscopy. Results：Chromophobe cells with distinct membranes were larger and polygonal with translucent and finely reticulated cytoplasm. Eosinophilic cells had eosinophilic cytoplasm and perinuelear halo. Wrinkled, grooved and bizarre nuclei were found in chromophobe cell renal carcinoma . Immunohistochemically, the tumors expressed EMA （23/ 23）, CD10 （11/23）, vimentin （0/23）, CK7 （17/23）, CDll7 （22/23）. Sarcomatoid transformation was found in 2 cases （9%）. 21 cases survived, and 2 cases died. Conclusions：Chromophobe cell renal carcinoma is an uncommon tumor. It has distinct morphologies, and diagnosis is easy with better prognosis, but the patient with sarcomatoid transformation has an extremely poor prognosis.
出处
《交通医学》
2009年第2期147-149,共3页
Medical Journal of Communications
关键词
肾嫌色细胞癌
临床病理
免疫组织化学
预后
Chromophobe cell renal carcinoma
clinical pathology
immunohistochemistry
prognosis
