摘要
肾脏是人体血流量丰富,耗氧量最大的主要脏器之一。药物主要是帮助机体对抗疾病,同时药物也可以引起组织器官的损伤。由于大部分药物及其代谢产物经由肾脏排出体外,大大增加了药物对肾功能损伤的机率。因此,研究药物对肾脏的毒性作用并弄清药物所导致的肾损伤的作用机制,就显得尤为重要。这对于开发新药和临床合理用药均有着重要的意义。本文就目前引起肾损伤药物和引起损伤的相关机制进行综述。
Kidney is the one of the main organs which has rich blood and big oxygen consumption in body.Drugs are mainly used to help body against diseases,but it also can produce damages to organs.Most of the drugs and their metabolites excrete through kidney;therefore,renal drug concentration dramatically increased and it probably brings about damages to kidney.To investigate the mechanism of drug induced kidney injuries is particularly important to protect kidney far from damages and to reduce risks of drug development and renal drug usage in clinics.This article aims at summarizing researches on mechanisms of drugs induced acute kidney injuries.
出处
《现代生物医学进展》
CAS
2012年第7期1380-1383,1322,共5页
Progress in Modern Biomedicine
基金
广东省"211工程"三期重点学科建设项目[粤发改社(2009)972号]
关键词
药物
肾损伤
机制
毒性
Drugs
Kidney injury
Mechanism
Toxicity
