摘要
本文比较了近交系615、TA_1、BALB/C 小鼠和远交系 NIH、昆明小鼠感染日本血吸虫和应用吡喹酮治疗的敏感性差异。结果表明,615、TA_1 及 BALB/C 小鼠对日本血吸虫的抗力和使用吡喹酮的效力均明显高於昆明小鼠,而NIH小鼠则居於上述两者效应之间,即既对血吸虫易感又对吡喹酮敏感,且繁殖能力强、适应性高,是国际通用的远交系小鼠,故建议以NIH小鼠为血吸虫实验研究的首选动物。
Three inbred strains of mice i. e. 615, TA1, BALB/C, as well as two outbred strains NIH and Km experimentally were used for studying the sponse to praziquantel treatment.Worm burden recovered from mice sacrificed 42 days after infection showed that the number in 615, TA1, BALB/c inbred mice were significantly lower than that in NIH, Km outbred mice.It merits Our attention that resluts obtained from the present study also indicated that the NIH mice was not only more susceptible to S. japonivum but also sensitive to praziquantel. NIH strain of mice may be, therefore, recommended as a prior animal for experiment on S. japonicum.
出处
《中国人兽共患病杂志》
CAS
CSCD
北大核心
1990年第5期24-26,共3页
Chinese Journal of Zoonoses
关键词
日本吸虫
吡喹酮
小鼠品系
感染
Different trains, Susceptibility S. japonicum, Praziquantel.
