摘要
目的研究血清同型半胱氨酸(Hcy)与勃起功能障碍(ED)的关系,以及Hcy对其严重程度的影响。方法测定50例ED患者和50例健康男性(对照组)血清Hcy水平,同时记录两组患者年龄、血脂、血糖、前列腺增生(BPH)及国际勃起功能指数5项(IIEF-5评分)。并对其进行Logistic回归分析,分析它们之间的关系。结果 ED组的Hcy水平明显高于对照组,差异具有统计学意义(P=0.013);ED组的高同型半胱氨酸血症(HHcy)比率(51%)明显高于对照组(12%),差异具有统计学意义(P=0.020)。ED组高脂血症、高血糖及BPH患者的Hcy与正常血脂、血糖及无BPH患者的Hcy相比差异无统计学意义(P=0.663,P=0.203,P=0.715)。HHcy患者的IIEF-5评分明显低于正常Hcy患者的IIEF-5评分(P=0.017)。多元Logistic回归分析显示HHcy为ED的独立危险因素(OR3.04,95%CI1.39～6.63,P<0.001)。结论高同型半胱氨酸血症与勃起功能障碍的危险性增加有关,并与其严重程度呈正相关。
Objective To investigate the relationship between plasma homocysteine（Hcy） and erectile dysfunction（ED）,as well as the impact of Hcy on severity of the disease.Methods Determined levels of plasma Hcy in 50 cases of ED patients and 50 healthy cases,and recorded their age,lipids,glucose,benign prostatic hyperplasia（BPH）,and international index of erectile function 5 items（IIEF-5）.Furthermore,the relationships between them were analyzed by Logistic regression analysis.Results The level of Hcy of ED group was significantly higher than that of control group（P = 0.013）;and the proportion of high Hcy patients of the ED group（51%） was significantly higher than that of control group（12%）,the difference was statistically significant（P = 0.020）.In ED group,there was no significant difference in Hcy between patients with hyper-lipids,diabetes,BPH and patients without them（P = 0.663,P = 0.203,P = 0.715）.IIEF-5 score of high Hcy patients was significantly higher than that of normal Hcy patients（P = 0.017）.The analysis of multivariate stepwise Logistic regression showed that high Hcy was an independent risk factor for ED（OR 3.04,95%CI 1.39-6.63,P 0.001）.Conclusion High Hcy is a risk factor of erectile dysfunction,and it can increases the severity of the disease.
出处
《中国当代医药》
2012年第12期73-74,76,共3页
China Modern Medicine
