摘要
目的:观察甲钴胺肌注、静滴与椎管内注射3种不同给药方式治疗2型糖尿病神经病变的疗效。方法:108例2型糖尿病合并痛性神经病变患者,根据甲钴胺不同给药方式分为A组(36例)、B组(36例)与C组(36例)。A组甲钴胺0.5 mg肌注,qd;B组甲钴胺1.0 mg静滴,每2天1次;C组甲钴胺2.0 mg椎管内注射,每4天1次。每组均加前列地尔注射液100μg辅助治疗,疗程均为20 d。治疗前后分别测定运动神经传导速度和感觉神经传导速度,并判断疗效。结果:A、B、C组总有效率分别为78%,89%和97%,3组间疗效比较差异有统计学意义(P<0.05)。3组治疗前正中神经、腓神经传导速度无明显差异,治疗后3组正中神经、腓神经传导速度均明显增加,B组与C组更为显著,与A组比较,差异有统计学意义(P<0.01)。结论:甲钴胺不同给药方式均可明显改善2型糖尿病神经病变,静滴与椎管内注射的疗效明显优于肌注,椎管内注射更为显著。
Objective： To research the curative effect of mecobalamine on type 2 diabetes with diabetic neuropathy by intramuscular injection,intravenous drip or vertebral canal injection.Method： Total 108 samples of type 2 diabetes with diabetic neuropathy were divided into 3 groups with various mecobalamine administrations.0.5 mg Mecobalamine was intramuscularly injected in group A once a day,1mg ecobalamine was intravenously dripped in group B once every 2 days and 2mg Mecobalamine was intraspinally injected in group C once every 4 days.Every group was combined with alprostadil 100μg therapy and the duration was 20 days.Motor nerve conduction velocity and sensory nerve conduction velocity were respectively measured before and after treatment,and the curative effects were examined.Result： The total effective rate of the three groups was 78%,89% and 97%,respectively with significant difference（P0.05）.There was no statistical difference in median and peroneal nerve conduction velocity among the groups before the treatment.After the administration,the nerve conduction velocity in the three groups was all increased,and compared with group A,group B and C had faster velocity（P0.01）.Conclusion： Mecobalamine with various administrations can significantly improve the curative effect on type 2 diabetes with diabetic neuropathy,and intravenous drip and intraspinal injection are better than intramuscular injection with intraspinal injection the best.
出处
《中国药师》
CAS
2012年第4期526-528,共3页
China Pharmacist
关键词
甲钴胺
糖尿病
神经病变
给药方式
Mecobalamine
Diabetes
Diabetic neuropathy
Administration
