摘要
目的探讨hs-cTnT在2型糖尿病患者中的检出率及升高率,以及2型糖尿病患者hs-CRP与hs-cTnT的相关性。方法本研究选取2型糖尿病患者299例作为糖尿病组,选取588例无2型糖尿病史的社区体检者作为对照组,所有受试者均进行病史采集、体格检查、肝功、肾功、空腹血糖、餐后2 h血糖、血脂、高敏C反应蛋白、hs-cTnT等项指标。结果 2型糖尿病组患者血hs-cTnT的检出率及升高率均高于非糖尿病组(P<0.05),年龄(r=0.291 9,P<0.001)、BMI(r=0.082 1,P=0.015)、SBP(r=0.114 8,P=0.001)、FBG(r=0.224 9,P<0.001)、OGTT2h(r=0.270 7,P<0.001)、hs-CRP(r=0.146 9,P<0.001)分别与lnhs-cTnT呈正相关,HDL-C(r=-0.136 0,P<0.001)、eGFR(r=-0.119 3,P<0.001)分别与lnhs-cTnT呈负相关。逐步回归分析显示:年龄、男性、FBG、OGTT2 h、eGFR、hs-CRP是hs-cTnT的独立危险因素。结论 2型糖尿病患者中出现心肌损伤的比例高于非糖尿病人群(P<0.05),且血hs-cTNT水平与多项心血管事件危险因素相关,其中hs-CRP是hs-cTNT的独立危险因素。
Objective To investigate the detected and elevated rate of hs-cTnT,and explore the relationship between hs-CRP and hs-cTnT in type 2 diabetes patients were researched.Methods The 299 patients with type 2 diabetes were recruited as diabetes group,588 subjects without type 2 diabetes were recruited as control group.The history of illness,physical examination,lab tests were collected and measured.Results Compared with control group,both the detected rate and the elevated rate of hs-cTnT were higher in the diabetes group（P0.05）.There showed positive correlations between hs-CRP（r=0.1469,P0.001）and lnhs-cTnT.Results from stepwise regression analysis revealed that hs-CRP was one of the independent risk factors of hs-cTnT in type 2 diabetes.Conclusion The prevalence of myocardial injury in type 2 diabetes group is higher than that in control group.There are correlations between hs-cTNT and multiple cardiovascular risk factors.hs-CRP is one of the independent risk factors of hs-cTnT.
出处
《实用医药杂志》
2012年第4期289-292,共4页
Practical Journal of Medicine & Pharmacy
基金
北京市首都医学发展科研基金重点支持项目(No.2009-2038)
关键词
高敏C反应蛋白
高敏心肌肌钙蛋白T
糖尿病
相关因素
High-sensitivity cardiac troponins T
High-sensitivity C reactive protein
Diabetes mellitus
Related factors
