摘要
目的评价抗环瓜氨酸肽(CCP)抗体和类风湿因子(RF)在类风湿关节炎(RA)中的意义。方法收集60例RA患者及60例非RA患者,测定其抗CCP抗体和RF水平,评价对RA诊断的敏感性、特异性,比较RA患者中抗CCP抗体、阴性组的压痛关节数、肿胀关节数、红细胞沉降率(ESR)、C反应蛋白(CRP)、疾病活动指数(DAS)。结果抗CCP抗体的特异度为92.9%,联合检测抗CCP抗体和RF有任何一种及以上阳性的灵敏度最高,为95.5%。抗CCP抗体阳性组与阴性组的关节肿胀数、关节压痛数、ESR、CRP、DAS差异有统计学意义(P<0.05)。结论抗CCP抗体与RF联合检测对诊断RA有意义,抗CCP抗体与RA的活动度相关。
Objective To evaluate the significance of rheumatoid factor（RF） and anti-cyclic citrullinated peptide antibodies（ACCP） in patients with rheumatoid arthritis（RA）.Methods Sixty cases of RA and sixty cases of non-RA were selected to detect the serum levels of RF and ACCP.The sensitivity and specificity for the diagnosis of RA were evaluated.The association between ACCP and number of tender joints and swollen joints,ESR,CRP,disease activity score（DAS） in patients with RA were statistically analyzed.Results The specificity of ACCP was 91.9%.RF and ACCP were all sensitive markers for the diagnosis of RA and the sensitivity could be up to 95.5% when one of these markers was positive.There were statistical differences in the number of swollen joints,ESR and DAS between ACCP positive group and ACCP negative group（P〈0.05）.Conclusions Combined detection of ACCP and RF is useful in routine RA diagnosis.ACCP clinical markers are valuable in predicting rheumatoid arthritis activity and prognosis.
出处
《临床医学工程》
2012年第4期549-550,共2页
Clinical Medicine & Engineering
关键词
关节炎
类风湿
类风湿因子
抗环瓜氨酸肽抗体
Arthritis
Rheumatoid
Rheumatoid factor
Anti-cyclic citrullinated peptide antibodies
