摘要
目的探讨抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断意义,并了解其与IgM型类风湿因子(RF)之间的相关性。方法ELISA法检测55例RA、47例非RA的风湿病例、30例正常人血清的抗CCP抗体,然后采用相关方法进行统计分析。结果55例RA病人中,抗CCP抗体阳性41例,抗CCP抗体对RA诊断的阳性率为74.5%;特异性为90.4%(47/52)。55例RA中抗CCP抗体与RF同时阳性31例,同时阴性6例,两者一致率为67.3%。抗CCP抗体与RF抗体的相关性无统计学意义(P>0.05)。抗CCP抗体与RF联合检测的敏感性为89.1%。结论抗CCP抗体是一种新的对RA有较高诊断价值的血清学标记物。抗CCP抗体与RF联合检测更有助于RA的诊断。
Objective To explore the diagnostic value of anti-cychc citrullinated peptide antibody （anti-CCP ） in patients with rheumatoid arthritis （RA）, and the relationship with IgM rheumatoid factors （RF）. Methods Anti-CCP were tested by an enzyme linked immunosorbent assay （EUSA） in serum samples from 55 patients with RA,47 non-RA controls with various rheumatic disease, and 30 healthy indivMuals. Results The diagnostic sensitivity of anti-CCP for RA was 74.5 % （41/55）, and specificity was 90.4% （47/52）. Out of 55 anti-CCP positive sera,31 were positive for IgM-RF,and 6 anti-CCP negative sera,6 were negative for IgM-RF. No significant association was found between anti-CCP and IgM-RF. Conclusion Anti-CCP is a valuable diagnostic tool and a useful additional marker for RA,The detection of anti-CCP is useful for the diagnosis of RA,especially combined with IgM-RF.
出处
《四川医学》
CAS
2006年第7期690-691,共2页
Sichuan Medical Journal
关键词
类风湿关节炎
抗CCP抗体
RF
酶联免疫吸附法
rheumatoid arthritis
anti-cyclic citruUinated peptide （anti-CCP）
rheumatoid factors
Enzyme-linked immunnosorbent assay （EUSA）
