摘要
富亮氨酸重复序列(leucine-rich repeat,LRR)是一种常见的蛋白质结构域.含有富亮氨酸重复序列的蛋白质简称LRR蛋白.LRR蛋白在真核生物和原核生物的细胞和组织中广泛分布,其定位的特异性以及与之相互作用蛋白质的复杂性,决定了LRR蛋白功能的多样性.许多LRR蛋白相对特异性表达于神经系统,绝大多数在神经系统中高表达的LRR蛋白属于跨膜蛋白,它们主要作为细胞黏附分子或配体结合蛋白参与突触的形成、神经突起的生长发育、神经递质的转移和释放等神经系统正常生理活动.LRR蛋白的异常表达将会导致神经、精神系统疾病的发生.
Leucine-rich repeat（LRR） is a common protein domain.LRR domain-containing proteins are present in a large number of cells and tissues in prokaryotes and eukaryotes.The diverse functions of LRR proteins due to their specific locations and the different proteins interacted with them.Many LRR proteins are expressed specially in nerve tissue,and most of the proteins overexpressed in nerve tissue belong to transmembrance protein.As cellular adhesive molecules or ligand receptor proteins,they are involved in a variety of neural physiological activities such as synapse formation,neurite growth,neurotransmitter trafficking and release.The abnormal expression of LRR proteins results in the neurological and psychiatric disorders.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2012年第4期314-318,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(81171932)
湖南省自然科学基金杰出青年基金(11JJ1013)资助项目~~
关键词
富亮氨酸重复序列
跨膜蛋白
神经系统
结构
功能
leucine-rich repeat
transmembrane protein
nervous system
structure
function
