摘要
目的研究呼和浩特地区汉族老年男性髋部骨折患者雌激素受体基因多态性与骨质疏松症的关系。方法收集老年男性髋部骨质疏松性骨折128例,按年龄配比选取汉族男性健康体检者128名,进行病例对照研究。所有受试者均行骨密度检查,并进行雌激素受体基因多态性检测。结果骨质疏松组雌激素受体PvuⅡ基因型PP、Pp及pp频率分别为7.8%,42.2%和50.0%;对照组雌激素受体PvuⅡ基因型PP、Pp及pp频率分别为13.3%,53.9%和32.8%,卡方检验提示,骨质疏松组和对照组之间Pp,pp,PP三种基因型的频率分布差异有显著性意义(P<0.05)。骨质疏松组雌激素受体XbaI基因型XX、Xx及xx频率分别为4.7%,44.5%和50.8%;对照组雌激素受体PvuⅡ基因型XX、Xx及xx频率分别为3.1%,39.1%和57.8%,卡方检验提示,骨质疏松组和对照组之间XX、Xx及xx三种基因型的频率分布差异无显著性意义(P>0.05)。结论雌激素受体基因型分布频率均符合Hardy-Weinberg定律,呼和浩特地区老年男性ERα基因基因PvuⅡ酶切位点与原发性骨质疏松症存在相关性。老年髋部骨折与雌激素受体基因多态性可能存在相关性。
Objective To investigate the relationship between estrogen receptor（ER） gene polymorphism and osteoporosis in Han elderly males with hip fracture in Hohhot.Methods One hundred and twenty-eight elderly male patients with hip osteoporotic fracture were enrolled.One hundred and twenty-eight healthy people were enrolled and matched with age to conduct a case-control study.The bone mineral density and ER gene polymorphism measurement were performed to all subjects.Results The frequencies of ER PvuⅡgenotype PP,Pp,and pp were 7.8%,42.2%,and 50.0%,respectively,in the osteoporosis group.The frequencies of ER PvuⅡgenotype PP,Pp,and pp were 13.3%,53.9%,and 32.8%,respectively,in the control group.ANOVA test indicated that the difference of ER PvuⅡgenotype frequency between the osteoporosis group and the control group was statistically significant（P0.05）.The frequencies of ER XbaI genotype XX,Xx,and xx were 4.7%,44.5%,and 50.8%,respectively,in the osteoporosis group.The frequencies of ER XbaI genotype XX,Xx,and xx were 3.1%,39.1%,and 57.8%,respectively,in the control group.ANOVA test indicated that the difference of ER XbaI genotype frequency between the osteoporosis group and the control group was not statistically significant（P0.05）.Conclusion All frequency distribution of ER genotypes is fit for Hardy-Weinberg equilibrium.ER gene PvuⅡRFLP is related to osteoporosis in Han elderly males in Hohhot area.Elderly hip fractures may be associated with ER gene polymorphism.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2012年第3期210-213,共4页
Chinese Journal of Osteoporosis
