摘要
目的 分析我国小儿重症肌无力 (MG)的临床特点。方法 回顾性分析 195 6～ 1999年诊治的 1381例小儿MG病例资料 ,并与同时期诊治的 10 6 9例成人期MG进行对比。结果 同期小儿MG的患病人数较成人多 ,性别差异较小 ,发病年龄以 1～ 5岁为主 ,因各类药物、感染及外伤而诱发或加重者较多 ,以眼肌症状首发者多见 ,改良Osserman分型以Ⅰ型为主 ,危象发生率及病死率低 ,合并胸腺瘤者少见。结论 本文小儿MG的临床特点不同于成人期及国外报道 ,充分认识此特点将有利于指导临床的诊断和治疗。
Objective To study the clinical characteristics of myasthenia gravis(MG) in children in China.Methods Retrospective study was done on 1381 children who were diagnosed and treated at Tongji Hospital from 1956 to 1999.Results (1)Children-onset MG accounts for 56 4% in all patients with MG.(2)There were little difference of quantity between male and female.(3)The ages of onset were mostly during 1～5 years.(4)Drugs and infection and trauma are risky factors of MG in childhood.(5)The ocular muscular symptom was most frequently involved at the onset,and according to modified Osserman criterion there were more type Ⅰ patients than any other types.(6)The incidence rate of myasthenia crisis and the mortality rate were low.(7)Childhood-onset MG associated with thymoma is less than adult patients.Conclusion The children MG in China has its own clinical characteristics.With the important information of the clinical manifestation available,it may facilitate the diagnosis and therapy in children with MG.
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第5期282-284,共3页
Chinese Journal of Practical Pediatrics
