摘要
目的 比较优势侧有抽搐电休克 (ECT)与无抽搐ECT治疗精神分裂症的疗效、副作用及心电图 (ECG)、脑电图 (EEG)的改变。方法 在ECG、EEG监护下ECT治疗精神分裂症 6 0例 (有抽搐ECT 30例 ,无抽搐ECT 30例 ) ,并完成简明精神症状量表 (BPRS)、大体评定量表 (GAS)、副反应量表(TESS)、韦氏记忆测验 (WMS)评定。结果 有抽搐ECT组和无抽搐ECT组的疗效均随治疗次数的增加而提高 ,治疗前后BPRS总分的差异均有非常显著性 (有抽搐ECT组t=9 4,P <0 0 1;无抽搐ECT组t=6 2 ,P <0 0 1)。两组间疗效的差异无显著性 (t=1 4,P >0 0 5 )。GAS评定也显示类似上述结果。BPRS减分率≥ 5 0 %者的病期与疗效有关 ,≤ 12个月者中减分率≥ 5 0 %者占 5 5 % (14/2 6 ) ,>12个月者中减分率≥ 5 0 %者为 6 % (2 /34 ) ,两者间差异有非常显著性 (χ2 =17 3,P <0 0 1)。EEG监护显示 ,有抽搐ECT组第 5 ,9次ECT后EEG的异常率及严重程度高于无抽搐ECT组 ;无抽搐ECT组抽搐慢波期有递减趋势。ECT后的ECG主要表现为心率加快 ,其中以有抽搐ECT组更为明显。两组的记忆损害均不明显。结论 无抽搐ECT与有抽搐ECT的疗效相当 ,无抽搐ECT带给患者的痛苦小。
Objective The purpose of this research was to compare the effect, side effect, changes of electroencephalogram (EEG) and electrocardiograph (ECG) between dominant side electro convulsive therapies (ECT) with or without convulsion Methods 60 schizophrenia patients (30 cases with convulsion, 30 cases without convulsion) were assessed with Brief Psychiatry Rating Scale (BPRS), Treatment Emergent Symptom Scale (TESS), Global Assessment Scale (GAS)and Wechsler Memory Scale (WMS) The ECG and EEG were monitored during ECT Results The effects of ECT in two groups were increased with the increment of ECT times, and the scores of BPRS were significantly changed before and after treatment( t =9 4, P <0 01 and t =6 2, P <0 01 respectively) But there no significant difference of BPRS score changes found between two groups( t =1 4, P >0 05) The similar result was showed assessed with GAS The effect was correlated to the course of illness The significant difference was found between the patients with illness courses shorter than 12 months(55%, 14/26)and those with longer than 12 months(6%,2/34),χ 2=17 3, P <0 01 The memory impairment was not significant in both groups, the slow wave of EEG showed a trend to decrease in the group without convulsion Conclusions It is suggested that ECT without convulsion more suitable and less suffering using than that with convulsion
出处
《中华精神科杂志》
CAS
CSCD
2000年第2期96-99,共4页
Chinese Journal of Psychiatry
