摘要
目的 探讨 nm2 3- H1m RNA及其蛋白低表达之间相关性及与乳腺癌生物学行为的关系。方法 应用 RT/ PCR及免疫组化方法对 5 8例乳腺癌组织中 nm2 3- H1m RNA及其蛋白的表达进行检测。结果 分别有 44 .8%、48.2 %的乳腺癌伴有 nm2 3- H1m RNA或该基因编码蛋白的低表达 ,nm2 3- H1m RNA与其蛋白表达虽有相关性 ,但并不完全吻合。低水平的 nm2 3- H1m RNA或其蛋白质表达与乳腺癌淋巴转移呈显著关系。结论 通过 nm2 3- H1表达水平的检测对乳腺癌的转移潜能及预后有一定的意义。
Objective To explore the expression of nm23 H1 mRNA and its protein in breast cancer and its correlation to the biologic behavior.Methods RT PCR and immunohistochemical method were employed to detect the expression of nm23 H1 mRNA and its protein in 58 breast cancer tissues. Results Low level expression of nm23 H1 mRNA and protein was shown in 44.8% and 48.2% of examinated cases respectively. The low expression of nm23 H1 mRNA was correlated, but not always parallel to the protein expression. The low level expression of nm23 H1 mRNA or the protein was significantly associated with lymphatic metastasis of the cancer.Conclusion Examination of nm23 H1 expression may be of significance in evaluating metastatic potentiality and prognosis of breast cancer.
出处
《中华医学遗传学杂志》
EI
CAS
CSCD
北大核心
2000年第2期91-93,共3页
Chinese Journal of Medical Genetics
