摘要
目的探讨NSCLC患者血清中转化生长因子β(1TGF-β1)和血管内皮生长因子(VEGF)的表达及其临床意义。方法用双抗体夹心酶联免疫吸附法(ELISA)检测58例NSCLC患者术前血清和29例健康体检者血清中TGF-β1和VEGF的水平,比较两组血清TGF-β1和VEGF表达水平的差异以及与临床病理特征的关系。结果 58例NSCLC患者血清中TGF-β1和VEGF水平均显著高于健康者(P<0.01),血清TGF-β1和VEGF的表达水平与病理分化低、临床分期晚及淋巴结转移呈正相关关系(P<0.01),而与性别、年龄、病理类型等差异均无统计学意义(P>0.05);血清TGF-β1表达水平与VEGF水平呈正相关(P<0.01)。结论 TGF-β1和VEGF可能共同参与了NSCLC血管生成的作用,从而促进NSCLC的发生、发展和转移。
Objective To measure serum levels of TGF-β1 and VEGF in patients with non-small cell lung cancer（NSCLC） and de-termine their clinical significance.Methods Serum levels of TGF-β1 and VEGF were determined by ELISA in 58 patients with NSCLC before surgery and in 29 healthy volunteers.Serum levels were compared between the two groups,and associations of serum levels with clinicopathological features were explored.Results Serum levels of TGF-β1 and VEGF were significantly higher in patients than in controls（P0.01）.Among patients,serum levels of TGF-β1 and VEGF were higher in patients with poorly differentiated tu-mors,patients in clinical stage III ＋ IV and patients with lymph node metastasis（P0.01）.Sex,age and NSCLC pathology were not as-sociated with serum levels of TGF-β1 or VEGF（P0.05）.Serum levels of TGF-β1 and VEGF were positively correlated in NSCLC pa-tients but not in controls（P0.05）.Conclusion TGF-β1 and VEGF may participate in NSCLC angiogenesis,and promote the develop-ment and/or transfer of NSCLC.
出处
《中国癌症防治杂志》
CAS
2012年第1期49-52,共4页
CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
基金
广西自然科学基金资助项目(桂科自0991233)
