摘要
目的评价长期服用帕罗西汀、舍曲林SSRIs类药物对于早泄的有效性和安全性。方法将符合“早泄诊断工具”早泄标准的190人随机分为5组：行为治疗组（采用性行为暂停．阴茎挤捏法，A组）、口服帕罗西汀片（赛乐特）20mg／d（B组）、帕罗西汀中30mg／d（C组），和口服舍曲林片（左洛复）50mg／d（D组）、舍曲林片100mg／d（E组）。并于治疗前、治疗6周后及治疗12周后监测阴道内射精潜伏期（IELT）、性生活满意度及常见的不良反应。结果最终144人完成随访。于治疗6周后各治疗方式IELT均高于治疗前，差异具统计学意义（P〈0．05），口服帕罗西汀30mg较行为治疗延长IELT更显著，差异具统计学意义（P〈0．01）；于治疗12周后口服SSRIs各剂量组IELT均长于行为治疗组（P〈0．05）。口服帕罗西汀30mg12周后性生活满意率超过60％。12周内各治疗方式出现的困倦、头痛、失眠及腹泻不良事件比较，差异无统计学意义（P〉0．05）。结论帕罗西汀、舍曲林两类SSRIs药物能延长早泄患者IELT，改善性生活满意度，有效治疗早泄，并具良好耐受性，且以帕罗西汀疗效更为显著。
Objectives To evaluate the effect and safety of Paroxetine and Sertraline in the treatment of patients with premature ejaculation. Methods A total of 190 patients were enrolled in this randomized trial. They all met the criterion of the Premature Ejaculation Diagnosis Tool. They were divided randomly into Group A （treated with the pause-squeeze technique）,Group B （treated with 20mg/d Fluoxetine）, Group C （ treated with 30mg/d Fluoxeting）, Group D（ treated with 50mg/d Sertraline） and Group E （ treated with 100mg/d Sertraline）. Before treatment, 6 weeks and 12 weeks after treatment, the patients had to report about the intravaginal ejaculatory latency time （IELT）, sexual satisfaction, and adverse reaction. Results One hundred and four participants completed this study. After 6 weeks＇ treatment, IELT was prolonged significantly compared with that before treatment（P〈0.05）. It prolonged much in Group C compared with that in Group A （t=3.92, P〈0.01）; After 12 weeks, it was much longer in patients treated with Paroxetine and Sertraline than that in patients treated with the pause-squeeze technique. The ratio of sexual satisfaction was increased significantly in Group C, which exceeded 60%. The common adverse reaction in a long period of treatment with Paroxetine and Sertraline was drowsiness, headache, insomnia and diarrhea, but no significant difference was found among the groups in terms of the adverse reaction ratio （x^2=2.90, P〉0.05）. Conclusion Paroxetine and Sertraline are able to manage premature ejaculation through prolonging IELT and improving sexual satisfaction, Moreover, they can be well tolerated, and especially Paroxetine is superior to Sertraline.
出处
《中国男科学杂志》
CAS
CSCD
北大核心
2012年第2期41-43,47,共4页
Chinese Journal of Andrology
关键词
帕罗西汀
舍曲林
早泄/药物疗法
Paroxetine
Sertraline
Premature Ejaculation/drug therapy
