摘要
A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that \{1-benzyl\}-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.
A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that \{1-benzyl\}-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2000年第1期79-81,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金! (批准号 :2 9832 0 4 0 )资助
