摘要
目的:优选八珍益智颗粒制备工艺。方法:以总多糖提取率和浸膏得率为评价指标,采用L9(34)正交设计试验法,对八珍益智颗粒制备过程中的水提取工艺条件进行优化,并进行制粒工艺研究。结果:该颗粒剂水提取最佳工艺条件为分别加12,10倍水提取2次,每次2 h,每次提取前先浸泡0.5 h;制粒工艺为提取液减压浓缩后喷雾干燥得药粉,以90%乙醇作润湿剂,药粉-辅料1∶0.3,矫味剂用量为2.0%。结论:该工艺合理可行,适用于八珍益智颗粒的制备。
Objective：To optimize preparation technology of Bazhen Yizhi granule.Method： Using extraction rate of total polysaccharide and yield of extracts as the index,orthogoral design method was used to optimize water extraction technology conditions in preparation process of Bazhen Yizhi granule,and to study on granulating technology.Result： Optimal water extraction technology conditions were as follow： 12 and 10 times the amount of water soaked 0.5 h,extracted 2 times with 2 h each time;Granulating technology was：extraction liquid was spray dried after vacuum concentrated,wetting agent was 90% ethanol,extraction powder-accessories was 1∶0.3,2.0% flavoring agent was added.Conclusion： This technology was stable and feasible,it could be suitable for preparation of Bazhen Yizhi granule.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第7期34-37,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
科技人员服务企业行动项目(SQ2009GJG3004800)
关键词
八珍益智颗粒
制备工艺
多糖
正交试验
喷雾干燥
Bazhen Yizhi granules
preparation process
polysaccharides
orthogoral test
spray drying
