摘要
目的通过对输卵管妊娠患者血清人绒毛膜促性腺激素(β-HCG)、癌抗原125(CA125)联合检测,探讨两者在输卵管妊娠治疗中的临床价值。方法我院2008年3月～2010年12月治疗输卵管妊娠73例,根据血β-HCG值与生命体征平稳情况,分为手术治疗组32例和保守治疗组41例。手术治疗组根据手术及病理所见分为活跃型24例,流产型8例;保守治疗组依照治疗结果分为成功型36例,失败型5例。分别于治疗前后检测血清β-HCG、CA125的变化。结果血清β-HCG水平手术治疗组活跃型高于流产型,差异有统计学意义(P<0.05),保守治疗组失败型高于成功型,差异亦有统计学意义(P<0.05)。血清CA125水平活跃型与流产型比较,成功型与失败型比较,差异均有统计学意义(P<0.05)。但手术治疗组中8例流产型患者β-HCG水平>3000 U/L,其最佳治疗方案应为保守治疗;保守治疗组5例失败型患者β-HCG水平<3000 U/L,其最佳治疗方案应为手术治疗。血清CA125水平手术治疗组流产型与保守治疗组成功型比较差异无统计学意义(P>0.05);手术治疗组活跃型与保守治疗组失败型比较,差异亦无统计学意义(P>0.05),提示对于流产型患者进行药物治疗成功率较高。结论血清β-HCG、CA125联合检测比单纯检测β-HCG具有分辨力强、准确率高的优点,在输卵管妊娠患者选择治疗方法中具有很高的临床价值。
Objective According to combined detection of serum human chorionic gonadotropin（β-HCG） and Cancer antigen 125（CA125） of patients with tubal pregnancy,to discuss the clinical value of the therapy of tubal pregnancy.Methods 73 patients of tubal pregnancy during Mar.2008 and Dec.2010 were divided into operation treatment group（n=32） and conservative treatment group（n=41） based on serum β-HCG value and vital signs.According to surgical outcomes and pathological evaluation,operation treatment group was divided into active type with 24 patients and abortion type with 8 patients.According to therapy outcomes,conservative treatment group was divided into success type with 36 patients and failure type with 5 patients.Changes of serum β-HCG,CA125 levels were measured before and after treatment.Results The level of serum β-HCG of operation treatment group of active type was higher than that of abortion type,the difference was statistically significant（P0.05）,conservative treatment group of failure type was higher than that of success type,and the difference was statistically significant（P0.05）.The serum level of CA125 active type and abortion type had significant difference（P0.05）;success type and failure type also had significant difference（P0.05）.But the level of serum β-HCG of operation group of abortion type active was 3000 U/L,and its best treatment was conservative treatment.The level of serum β-HCG of conservative treatment of group failure type was 3000 U/L,and its best treatment was operation.The serum level of CA125 between abortion type and success type,there was no significant difference（P0.05）;and there was no significant difference in active type and failure type（P0.05）,so abortion type patients undergoing medicinal treatment may have a higher achievement ratio.Conclusion The advantages of combined detection of serum β-HCG and CA125 are presented by strong resolution and high accuracy rate compared to only serum β-HCG detection.It has an important value in select
出处
《临床误诊误治》
2012年第3期48-50,共3页
Clinical Misdiagnosis & Mistherapy
