摘要
目的探讨妊娠急性脂肪肝(AFLP)的临床表现及治疗方法。方法回顾性分析2005年1月—2011年6月收治的15例AFLP的临床资料。结果本组多以食欲缺乏、恶心、呕吐等消化道症状起病,总胆红素均有不同程度的升高,40.00%的患者肝脏影像学检查提示脂肪肝。并发症发生率依次为弥漫性血管内凝血60.00%、低血糖46.67%、急性肾衰竭40.00%、产后出血33.33%及肝性脑病33.33%。确诊后及时终止妊娠,予对症支持治疗。孕产妇及围产儿病死率分别为40.00%和33.33%,并发症多者预后差。结论 AFLP临床罕见,孕产妇及围产儿病死率高,及时终止妊娠及对症支持治疗可明显改善母婴的预后。
Objective To explore the clinical manifestations and therapeutic method of acute fatty liver of pregnancy（AFLP）.Methods The clinical data of 15 inpatients with AFLP during January 2005 and June 2011 were reviewed and analyzed retrospectively.Results At the beginning the 15 patients showed the alimentary canal symptoms such as anorexia,nausea,vomiting,and total bilirubin had different degrees of increase and 40.00% of patients were diagnosed fatty liver with liver imaging.Incidence rates of complications in turn were disseminated intravascular coagulation（60.00%）,low blood sugar（46.67%）,acute renal failure（40.00%）,postpartum hemorrhage（33.33%） and hepatic encephalopathy（33.33%）.Fatality rates of maternal and perinatal mortality were 40.00%（6/15） and 33.33%（5/15） respectively.The patients with more complications experienced poor prognosis.Conclusion The AFLP is rare in clinic,and fatality rates of maternal and perinatal mortality are high.The prognosis of maternal and child can be obviously improved by timely termination of pregnancy and correct treatment.
出处
《解放军医药杂志》
CAS
2012年第7期24-26,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
急性脂肪肝
妊娠末期
临床方案
妊娠并发症
Acute fatty liver
Pregnancy trimester
Clinical protocols
Pregnancy complications
