摘要
背景:截止目前仍难以找到一种良好的针对运动性脊髓损伤的治疗方法。随着干细胞技术的发展,应用干细胞技术治疗为运动性脊髓损伤修复带来了强大的潜力。目的:通过检索干细胞技术及其运动性脊髓损伤防治等方面的研究文献资料,探讨干细胞移植、干细胞神经营养因子以及基因修饰的干细胞疗法在脊髓损伤修复中的作用。方法:应用计算机检索PubMed数据库、万方数据库、维普数据库有关干细胞移植、干细胞神经营养因子以及基因修饰的干细胞疗法修复脊髓损伤的文章,英文检索时间为1987/2010,中文检索时间为1997/2010;英文检索词为"stem cells,transplantation,neurotrophic factor,sports spinal cord injury,rehabilitation",中文检索词为"干细胞;移植;神经营养因子;运动性脊髓损伤;康复治疗"。排除重复性、陈旧的文献,共保留37篇文献进行综述。结果与结论:以干细胞所具有的移植性、迁移性、自我更新和多向分化潜能等的优势,将干细胞技术应用于运动性脊髓损伤的修复也已成为必然。但运动性脊髓损伤修复过程中,由于多种细胞因子和基因参与了调控,其基本机制还不清楚,因此仍需要对干细胞移植、诱导分化机制及其基因治疗和营养因子的作用等多方面进行深入的研究。
BACKGROUND： Until now, it is still difficult to find a good method for the treatment of sports spinal cord injury. With the development of stem cells technology, stem cells for the treatment of spinal cord injury have a strong potential. OBJECTIVE： To investigate the effect of stem cells transplantation, stem cells nutritional factors and genetically modified stem cells on the treatment of spinal cord injury. METHODS： PubMed database, Wanfang database and Weipu database were used to search the research articles relate to stem cells transplantation, stem cells nutritional factors and genetically modified stem cells on the treatment of spinal cord injury from 1987 to 2010 in English and from 1997 to 2010 in Chinese, respectively. The key words were ＂stem cells, transplantation, neurotrophic factor, sports spinal cord injury, rehabilitation＂ in English and in Chinese. A total of 37 articles were selected to review after the repetitive and old articles were excluded. RESULTS AND CONCLUSION： Based on stem cells transplantation possess, mobility, self-renewal and multi-differentiation potential and other advantages, the stem cells technology in the rehabilitation of spinal cord injury in sports has become inevitable. However, as a variety of cytokines and genes were involved in the regulation during the repair of spinal cord injury in sports, the basic mechanisms was unclear yet. So the in-depth study of the function of stem cells transplantation, induced differentiation mechanism, gene therapy and nutritional factors were needed to be done.
出处
《中国组织工程研究》
CAS
CSCD
2012年第6期1129-1132,共4页
Chinese Journal of Tissue Engineering Research
