摘要
目的探讨围排卵期血清睾酮(testosterone,T)水平对氯米芬(clomiphene citrate,CC)抵抗的多囊卵巢综合征(P-COS)病人妊娠的预测作用。方法 60名CC抵抗的PCOS病人随机分为A组和B组。A组患者予以维生素E 100mg;B组患者予以二甲双胍1000mg;口服,每日2次,连续3个月作为预治疗。随后A组患者予以二甲双胍(1000mg口服,每日2次)、CC、尿促性腺激素(HMG)、人绒毛膜促性腺激素(HCG)促排卵;B组患者予以CC/HMG/HCG促排卵,连续3个月。另选30名正常排卵妇女作为对照组(C组)。促排卵周期及正常周期中测定患者排卵前后血清中生殖激素水平,并对妊娠和非妊娠周期排卵前后生殖激素水平进行比较。结果实验组A、B两组中共56人完成141治疗周期,A组中临床妊娠、非妊娠周期排卵后血清睾酮(T)水平分别为0.74±0.11ng/ml和0.95±0.16ng/ml,差异有显著意义(P=0.001);B组中临床妊娠、非妊娠周期排卵后T分别为0.70±0.04ng/ml和0.85±0.09ng/ml,差异有显著意义(P<0.001);C组30个周期中妊娠和非妊娠者排卵后血清T分别为0.73±0.05ng/ml和0.71±0.07ng/ml,差异无统计学意义(P>0.05);A、B组妊娠周期排卵后T水平与正常组相比差异无显著性,而非妊娠周期A、B组排卵后T水平显著高于C组(P<0.001)。结论二甲双胍治疗的CC抵抗的PCOS病人,排卵后血清T水平对妊娠具有一定的预测价值。
Objective To evaluate whether the testerone level around the ovulation period is related to the outcome of pregnancy in women with clomiphene citrate （CC） -resistant PCOS women. Methods Total 60 non - obese PCOS women with CC resistant PCOS women from Reproductive Health Centre from The Second Affiliated Hospital of Wenzhou Medical College were enrolled and randomly assigned to be treated with placebo （100mg） （ Group A） or mefformin （1000mg） （ Group B） twice daily for three months as the pre - treat- ment. Then metformin was administered along with CC, human menopausal gonadotropin （HMG） and human chorionic gonadotropin （HCG） to induce ovulation for three months in Group A. In Group B, CC/HMG/HCG was used to induce ovulation for three months with- out metformin. Group C （ n = 30） was the control group. Follicle stimulating hormone （FSH） , luteinizing hormone （LH） , estradiol （ E2 ） and testosterone （T） levels before and after ovulation in pregnant cycles and non - pregnant cycles were evaluated over the course of treat- ment. Results Total of 56 subjects completed 141cycles in group A and group B. The T levels after ovulation in the pregnant cycles were significantly lower than in the non - pregnant cycles in both groups （ P =0. 001 and P 〈 0. 001, respectively） ,which was as low as that of control group C. Conclusion The level of total T after ovulation may be of prognostic value for pregnancy in non - obese women with CC - resistant PCOS during treatment.
出处
《医学研究杂志》
2012年第3期103-107,共5页
Journal of Medical Research
关键词
睾酮
多囊卵巢综合征
促排卵
妊娠
Testosterone
Polycystic ovary syndrome
Ovulation induction
Pregnancy
