摘要
目的探讨轻度认知功能障碍(MCI)患者与认知功能正常的老年人海马的平均弥散系数(ADC)及部分各向异性(FA)值的差异,评估海马磁共振弥散张量成像(MR-DTI)在MCI患者诊断中的应用价值。方法采用MR-DTI对18例MCI患者(MCI组)和18例性别、年龄、文化程度匹配的对照组(NC组)DTI参数进行分析,比较两组间海马ADC和FA值的差别,并将MCI患者的简易智能精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)、日常生活能力量表(ADL)评分与其海马ADC、FA各自进行相关性分析。结果 MCI组与NC组比较:①双侧海马总ADC值及左侧海马ADC值明显增高(P<0.01),右侧海马ADC值略增高,差异不明显(P>0.05),左、右侧及双侧海马FA值无统计学差异(P>0.05);②MMSE、MoCA评分明显降低,ADL评分明显增高(P<0.01);③MMSE评分与左侧及双侧海马总ADC值呈明显负相关(P<0.01),MMSE评分与FA值及右侧海马ADC值无相关性(P>0.05),MoCA和ADL评分与ADC、FA值均无明显相关性(P>0.05)。结论磁共振弥散张量成像对轻度认知功能障碍患者有一定的诊断价值。
Objective To investigate the difference of average diffusion coefficient（ADC） and fractional anisotropy（FA） in the hippocampus（HP） of aged groups that have mild cognitive impairment（MCI） and that have normal cognition,and to evaluate the applicability of magnetic resonance diffusion tensor imaging（MR-DTI） in MCI diagnosis.Methods We selected a total of 18 MCI patients（MCI Group） and 18 individuals with normal cognition（NC Group）,the two groups being matched by gender,age and education.A comparison was done for the two groups in ADC and FA in the HP.A possible correlation between the ADC and FA values of the MCI patients and their Mini-Mental State Examination（MMSE）,Montreal Cognitive Assessment（MoCA）,and Activities of Daily Living（ADL） scores was examined.Results Compared with the NC Group,the MCI Group exhibited significantly high ADC for the left HP and the total bilateral HP（P0.01）,whereas the two groups were not significantly different in the right HP（P0.05）.With FA,the two groups were not significantly different in the left,right and total bilateral HP（P0.05）.The MCI Group had lower MMSE and MoCA scores,but higher ADL scores than the NC Group（P0.01）.In addition,MMSE showed a negative correlation with ADC of the left HP and total bilateral HP（P0.01）,but had no significant correlation with either FA or ADC of the right HP（P0.05）.Furthermore,MoCA and ADL did not have significant correlation with either ADC or FA（P0.05）.Conclusion MR-DTI is a helpful tool in MCI diagnosis.
出处
《山东大学学报（医学版）》
CAS
北大核心
2012年第3期103-107,共5页
Journal of Shandong University:Health Sciences
基金
山东省科技攻关项目(2009GG10002024)
山东省自然科学基金资助项目(ZR2009CL021)
关键词
磁共振成像
弥散张量成像
轻度认知功能障碍
海马
Magnetic resonance imaging
Diffusion tensor imaging
Mild cognitive impairment
Hippocampus
