摘要
目的探讨CC趋化因子受体7(CCR7)和黏附分子L-选择素在大肠癌组织中的表达及二者与大肠癌淋巴转移的关系。方法采用免疫组织化学方法检测63份大肠癌组织(大肠癌组)、44份癌旁正常组织(癌旁组)和31份转移灶组织(转移组)中CCR7和L-选择素的表达。结果大肠癌组、转移组CCR7、L-选择素阳性率明显高于癌旁组(P<0.01);CCR7与L-选择素表达显著相关(r=0.653,P<0.01);有淋巴结转移者明显高于无转移者,P<0.05。结论 CCR7与L-选择素在大肠癌中的表达与大肠癌的发生和淋巴转移有关,二者可能共同参与了大肠癌发生及淋巴结转移过程;检测二者表达情况有助于判断大肠癌患者的预后。
Objective To investigate the expression of chemokine receptor 7（CCR7）and adhesion molecule L-selectin in human colorectal carcinoma,and analyze their correlation with lymph node metastasis.Methods The expression of CCR7 and L-selectin were tested by immunohistochemical method in 63 cases of colorectal carcinoma specimens（colorectal carcinoma group）,44 cases of normal intestinal mucosa adjacent to carcinoma（adjacent group） and 31 cases of metastatic tumor tissue（metastasis group）.Results The positive rate of CCR7 and L-selectin expression in the colorectal carcinoma group and metastatic tumor tissue were significantly higher than that in adjacent group and metastasis group（P0.01）;There was significantly positive dependability between expression of CCR7 and L-selectin（r=0.653,P0.01）.The expression in the tissue with lymph node metastasis was significantly higher than that in the tissue without lymph node metastasis（P0.05）.Conclusions The expression of CCR7 and L-selectin are closely associated with development and metastasis of the colorectal carcinoma.CCR7 and L-selectin maybe participate together in the carcinogenesis and lymph node metastasis of colorectal carcinoma.Detection of the two marker conduces to judge the patient＇s prognosis.
出处
《山东医药》
CAS
2012年第7期35-37,共3页
Shandong Medical Journal
关键词
大肠癌
趋化因子受体
L-选择素
淋巴转移
colorectal carcinoma
chemokine receptor
L-selectin
lymphatic metastasis
