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胰高血糖素样肽-1对胰岛素分泌传导通路中胰十二指肠同源盒-1基因的调控作用

The role of GLP-I in the regulation of PDX-1 gene expression during the secretion of insulin
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摘要 胰高血糖素样肽-1(GLP-1)是-种肠促胰岛素,它通过多种复杂的机制使血糖降低的同时,促进胰岛β细胞增殖与再生;胰十二指肠同源盒-1(PDX-1)是β细胞内重要的转录因子,参与β细胞胰岛素基因的转录调控,GLP-1通过上调PDX-1基因蛋白的表达而影响胰岛β细胞增殖与再生。 Glucagon-like peptide-1 ( GLP-I ) is a kind of incretin,which contributes to the prolifera- tion and regeneration of beta cells as well as the reduction of glucose through complicated mechanism. Pancreatic duodenal homeobox factor-1 ( PDX-1 ) is one of the important transcription factors of Islet cells, participating the transcription of insulin gene in beta cells. GLP-1 affects proliferation and regeneration of beta cells by promoting the expression of PDX-1.
作者 吴美芬 武革
出处 《国际免疫学杂志》 CAS 2012年第2期118-120,共3页 International Journal of Immunology
基金 2011年广东省第一批科学事业费计划项目(20118031800231) 2011年广东省医学科学技术研究基金资助项目(B2011243) 2011年广东医学院青年基金资助项目(XQ1123)
关键词 糖尿病 胰岛素 胰高血糖素样肽-1 胰十二指肠同源盒-1 Diabetes mellitus Insulin Glucagon the peptide-1 Pancreatic duodenal homeobox factor-1
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参考文献18

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