摘要
目的探讨血清白细胞介素-18(IL-18)、C-反应蛋白(CRP)、24 h尿微量白蛋白(mALB)与2型糖尿病早期肾损害的关系。方法根据尿白蛋白排泄率(UAER)将105例2型糖尿病患者分为正常白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组,另选40例健康人作为对照组,观察各组血中IL-18、CRP、mALB水平并进行比较,同时进行相关分析。结果 2型糖尿病各组IL-18、CRP、mALB均高于对照组,各组间比较差异有统计学意义(P<0.05),且IL-18与CRP、mALB呈正相关(分别r=0.453,r=0.579,P均<0.01)。结论血清IL-18、CRP是2型糖尿病肾病发生的重要炎性反应介质,2型糖尿病患者血清IL-18、CRP、mALB水平的升高可能在糖尿病患者早期肾损害的发生及发展中起着重要作用。
Objective To explore the relationship between serum levels of interleukin-18,CRP and type 2 diabetes mellitus as well as renal impairment.Methods One hundred and five patients with type 2 diabetes were allocated into 3 groups as normal albuminuria,microalbuminuria and clinical albuminuria groups according to their urinary albumin excretion rate（UAER）.Forty healthy individuals with similar age range were selected as normal controls.The serum levels of interleukin-18 and CRP were observed,and correlation analysis was also done between IL-18 and CRP.Results The serum levels of IL-18 and CRP in patients with type 2 diabetes were significantly higher than those of controls（P0.05 andP0.01）.Pearson correlation analysis indicated that IL-18 was positively correlated to CRP and mALB（r=0.453,P0.01 and r=0.579,P0.01）.Conclusion Serum IL-18 is an important inflammatory mediator in the process and development of diabetic nephropathy.The increased serum levels of IL-18 and CRP have important significance in early development of nephropathy in patients with type 2 diabetes mellitus.
出处
《临床和实验医学杂志》
2012年第6期405-406,共2页
Journal of Clinical and Experimental Medicine
