摘要
以不同剂量黄芪培养人 3种肺癌细胞株后 ,采用 ELISA法分别测定上述细胞株的 IL- 2、IFN- γ含量。结果发现 :中剂量 ( 10 % )组的 3种肺癌细胞株 IL- 2及 IFN- γ水平明显高于对照组 ( P<0 .0 5 )。说明中剂量黄芪对 3种肺癌细胞株分泌 IL- 2及 IFN- γ均有一定诱生作用 ,可能通过促平衡或逆转肿瘤细胞的 Th2 状态而发挥其抗肿瘤作用。
Three human lung cancer cell lines were cultured with different doses of Astragulus(AG)and ELISA was performed for the quantitative measurement of IL 2 and IFN γ in those cell lines The levels of IL 2 and IFN γ in three lung cancer cell lines which is induced by the middle dose AG is significantly higher than that of the control(P<0 05) Our results suggest that a middle dose AG could induce IL 2 and IFN γ in human lung cancer cell lines,and a middle dose AG may suppress growth by regulating or switching the cytokine pattern of tumor cell lines from Th 2 type to Th 0/Th 1
出处
《山东医药》
CAS
北大核心
2000年第4期9-10,共2页
Shandong Medical Journal
基金
山东省科委立项课题
关键词
肺肿瘤
中医药疗法
黄芪
IL-2
IFN-Γ
Tumor cells,cultured Enzyme linked Immunosorbent Assay (ELISA) Astragulus(AG) Interlukine 2(IL 2) Interferon γ(IFN γ)
