摘要
目的 :探索经尿道给予前列腺素 E1( PGE1)治疗阳萎的可行性、安全性及剂量与效果关系。方法 :采用单盲、安慰剂及自身逐级增量给药 ( 1 50～ 1 2 0 0μg)对照观察 2 4例阳萎患者的剂量与效果 (阴茎勃起角度、周径、长度变化及持续时间 )的关系。结果 :60 0 μg以内剂量与反应呈直线正相关 ,随剂量增大阴茎勃起质量增加 ,80 %以上患者可达最佳效果 ;60 0 μg以上仅有 2 0 %以下的患者有进一步反应 ,且副作用增多。结论 :PGE1治疗阳萎疗效确实 ,安全可靠 ,单独使用剂量应控制在 60 0 μg以下。
Purpose: To investigate the feasibility, safety and relationship of the dose effectiveness of prostaglandin E1 (PGE 1) with medicated urethral system for erection (MUSE). Methods: A single blind, placebo controlled study of increasing dosages (150~1 200 μg) was done. 24 men with impotence were monitored in real time for 2 hours after MUSE, and penile erect angle (PEA), tumescence and duration of erection were measured. Results: The initial response to escalating doses of PGE 1 from 150 μg to 600 μg demonstrated a steep dose dependent increase, at greater than 600 μg indicating a nonliner response. More than 80% of the patients attained the maximal response at doses of 600 μg or less and less than 20% benefited from a further increase. Conclusions: The effects of PGE 1 with MUSE appear to limit to 600 μg or less, since larger amounts offer little additional benefit.
出处
《临床泌尿外科杂志》
2000年第3期112-114,共3页
Journal of Clinical Urology
关键词
阳萎
前列腺素E1
尿道内投药
Impotence Prostaglandin E 1 Intraurethral administration
