摘要
目的观察前列腺素E1(PGE1)注射治疗勃起功能障碍(ED)的长期疗效、副作用及预后。方法使用PGE1行阴茎海绵体注射,阴茎硬度检查仪(Rigiscan)连续记录1h,并根据观察结果,调查PGE1注射剂量,确定每例患者合适的注射量,掌握注射方法后回家自行注射。共筛选出ED患者410例,随访患者阴茎勃起情况、药量调整和副作用。结果410例ED患者中,心理性139例,静脉性83例,动脉性36例,神经性78例,混合性74例。对治疗满意的患者有256例(62.44%),其中21例(5.1%)在使用PGE15次后停用,并能达到满意的性生活而治愈。293例(71.46%)患者自述注射时有胀痛感。171例(43.17%)因疼痛(105例)、操作不便(25例)、副作用顾虑(37例)和其他原因(4例)而于6个月后放弃治疗。204例(49.76%)患者使用时间已超过1年,24例(5.85%)患者使用时间已超过5年,7例(1.7%)使用已有8年。未发现阴茎异常勃起和阴茎海绵体纤维化。注射损伤阴茎表面血管致瘀斑者有20例。有27例患者失访。结论PGE1是治疗ED的一种安全有效的药物,可以长期使用。其最常见的副作用是阴茎疼痛。Rigiscan能帮助确定PGE1的注射剂量。
Objective To summarize the efficacy, adverse events and prognosis of self-injection of aloprostadil sterille power （prostaglandin E1, PGE0 in 410 patients with erectile dysfunction （ED）. Methods The initial dosage of PGE1 was 10 μg, then was injected into corpus cavernosum penis near the radix penis with injection guns. Rigiscan was used to observe the response of penile erection in the following hours, Optimal injected dosage of each patient with positive reaction was determined. Injected dosage of patients with negative reaction was gradually increased from 20μg, 30 μg, 40μg, to 60 μg. As the dosage was established, drugs were taken back to home by the patients for self- injection. Follow-up was made in order to know the information of penile erection, dosage adjustment and adverse events. Results In 410 ED patients, 139 were considered as psychological, 83 venous, 36 arterial, 78 neurological and the other had combined causes （both psychological and organic）. The optimal dosage of PGE1 ranged from 10 to 60μg in hospital and from 7.5 to 60μg at home. The induced time of erection varied from 3 to 10 minutes, which was 3 to 25 minutes at home. The time of full erection was 8 to 32 minutes in hospital, however, 8 to 45 minutes of selfinjection. 293 patients （71.46%） had pains while injecting. 256 patients （62.44%） were satisfied with the treatment, of which 21（5.1%） patients （psychological ED 14, venous 6, and 1 arterial ED patient） stopped using PGE1 after using five times and healed well with contented sexual life. 171 patients （43.17%） gave up treatment after six months because of penis pain （105 patients）, inconvenient manipulation （25 patients）, worrying about side effect （37 patients） and other reasons （4 patients）. 204 （49.76%） had been using the treatment over one year, 24 patients had been using for over 5 years and 7 patients for over 8 years without finding priapism and corporal fibrosis. There were 20 patients with ecchymosis because of blood ves
出处
《中国男科学杂志》
CAS
CSCD
2007年第9期16-18,25,共4页
Chinese Journal of Andrology
