摘要
目的:观察探讨替比夫定治疗慢性乙型肝炎的临床疗效。方法:选择本院收治的60例慢性乙型肝炎患者,随机分为治疗组和对照组。两组患者同时给予口服甘草酸二铵治疗,治疗组另外给予口服替比夫定,对照组另外给予口服阿德福韦酯。观察对比两组患者在治疗后的第12、24、48、96周的血清检查结果。结果:两组第12周、24周时的HBV-DNA转阴率对比有显著差异(p<0.05),第48、96周治疗组患者的血HbeAg转阴率及HbeAg/抗Hbe血清转换率均较对照组有明显差异(P<0.05),具有统计学意义。结论:替比夫定治疗慢性乙型肝炎具有较好的疗效。
Objective：To observe the telbivudine treatment of chronic hepatitis B clinical efficacy.Methods：The hospital treated 60 patients with chronic hepatitis B were randomly divided into treatment and control groups.Two groups of patients while giving oral glycyrrhizic acid treatment,the treatment group also received oral telbivudine in the control group also received oral adefovir dipivoxil.Observed and compared two groups of patients after treatment of the first week of the serum test results 12,24,48,96.Results：There were 12 weeks,24 weeks of HBV-DNA negative rate compared with a significant difference（p 0.05）,the first weeks of treatment patients 48,96 HbeAg negative rate and blood HbeAg /seroconversion rate of anti-Hbe than in the control group were significantly different（P 0.05）,with statistical significance.Conclusion：telbivudine treatment of chronic hepatitis B with good effect.
出处
《求医问药（下半月刊）》
2011年第12期10-11,共2页
Seek Medical and Ask The Medicine
关键词
替比夫定
阿德福韦酯
慢性乙型肝炎
临床疗效
Telbivudine
adefovir dipivoxil
chronic hepatitis B
clinical curative effect
