摘要
MicroRNAs(miRNAs)是一类广泛存在于真核细胞中的长约21-22 nt的单链、非编码小RNA,具有转录后基因调控的功能,参与调控胚胎发育、细胞生长和凋亡、细胞分化、细胞能量代谢等多种生理过程以及糖尿病、心血管疾病、神经系统疾病、肿瘤等多种病理过程。近些年来研究发现,miRNAs与乳腺癌之间的关系十分密切。本文综述与乳腺癌发生、发展密切相关的miRNAs。
MicroRNAs（miRNAs） are single-strand,non-coding RNA molecules found in eukaryotic cells,with about 21～22 nucleotides in length.MiRNAs act as post-transcriptional regulators for target gene expression,involve in not only many physiological process such as embryonic development,cell growth,apoptosis,differentiation and energy metabolism,but also multiple pathological course such as diabetes,cardiovascular disease,nervous system disease and tumor.Recent researches demonstrated that miRNAs are closely associated with breast cancer.In this review,we summarized the miRNAs which play important roles during the development and progression of breast cancer.
出处
《实验与检验医学》
CAS
2012年第1期33-36,87,共5页
Experimental and Laboratory Medicine
基金
国家自然科学基金项目
编号:81060001
