摘要
目的对尘螨诱导引起变应性鼻炎的患者行白介素13-1112 C>T基因分型,探讨白介素13-1112 C>T基因与尘螨变应性鼻炎遗传易感性的相关性。方法用PCR-RFLP法对90名无亲缘关系的尘螨变应性鼻炎患者和107名无血缘关系的健康汉族人行白介素13-1112 C>T基因分型。结果尘螨变应性鼻炎组与对照组相比,白介素13-1112 C/T,C/C基因型频率均无显著性差异(P>0.05);但白介素13-1112位点的基因TT存在显著相关(P<0.05)。结论白介素13-1112 T/T基因多态性与尘螨变应性鼻炎存在相关性,可能存在原因较多,大样本和单倍体研究将可能有助于阐明关系。
Objective To investigate the distribution of interleukin-13 -1112 C〉T gene in a Guangdong and explore the association of these genes with allergic rhinitis patients infected with dust mite. Methods Interleukin-13 -1112 C〉T in 107 unrelated healthy individuals of Han nationality and 90 allergic rhinitis patients with dust mite from the same geographic region were enrolled in the study genotyped by PCR-RFLP technique. Results There was no significant difference between IL- 13 - 1112 CT and CC genotypes. The Tr genotype of IL 13 C- 1112T was increased, There was significant difference in IL-13 -1112 TT between rhinitis patients and control group （P〉0.05）. Conclusion The polymorphisms of IL13-1112 T/T were associated with allergic rhinitis patients infected with dust mite
出处
《中国热带医学》
CAS
2012年第1期67-69,共3页
China Tropical Medicine
基金
广东省社会发展领域科技计划项目(No.93091)
广州市番禺区科技局科技攻关项目(No.2009-Z-90-1)
