摘要
目的探讨双歧杆菌胶囊治疗便秘型肠易激综合征(irritable bowel syndrome,IBS)的疗效和安全性。方法50例便秘型IBS患者均采用双歧杆菌胶囊0.7g口服,每次2粒,每日3次,疗程为28d。观察50例患者临床症状的改善及临床疗效、不良反应等情况。结果 50例患者中,治愈8例,显效28例,有效10例,无效4例,总有效率为92.0%。50例患者治疗后腹痛发生时间、腹痛发生次数、排便时腹痛、腹胀和排便性状异常比率、排便次数异常比率评分均较治疗前明显下降(P<0.05)。在服药期间,发生腹泻1例,发热1例,经详细询问病史及行其他辅助检查后判定与服用双歧杆菌胶囊无关。结论双歧杆菌可明显地改善便秘型IBS的临床症状,且安全性高、耐受性好。
Objective To evaluate the curative effect and safety of Bifidobacterium capsules in patients with constipation-predominant irritable bowel syndrome.Methods Fifty cases of constipation-predominant irritable bowel syndrome were treated with oral Bifidobacterium capsules(0.7 g) three times per day(two capsules each time) for 28 days.The symptom improvement,curative effect,adverse reactions were observed in all patients.Results Among the 50 patients,complete cure was achieved in 8 and Bifidobacterium treatment was markedly effective in 28,effective in 10 and ineffective in 4 patients,with a total effective rate was 92.0%.After treatment with Bifidobacterium capsules,occurrence time of abdominal pain,frequency of abdominal pain,abdominal pain during defecation,abdominal distention and abnormal defecation trait ratio,rate of abnormal defecation number decreased significantly(P<0.05).During treatment with Bifidobacterium capsules,diarrhea occurred in 1 patient and fever in 1 patient.These two symptoms were not related to Bifidobacterium capsules through detailed history inquiry and other auxiliary examinations.Conclusion Bifidobacterium can effectively improve clinical symptoms of constipation-predominant irritable bowel syndrome with good safety and tolerability features.
出处
《南昌大学学报（医学版）》
CAS
2011年第12期30-32,共3页
Journal of Nanchang University：Medical Sciences
关键词
肠易激综合征
便秘型
双歧杆菌胶囊
不良反应
疗效
irritable bowel syndrome,constipation-predominant
Bifidobacterium capsules
adverse reactions
curative effect
