摘要
目的检测。肾病综合征（NS）患者血浆中可溶性内皮细胞蛋Sc受体（sEPCR）及血栓调节蛋白（sTM）的水平，初步探讨其临床意义。方法采用酶联免疫双抗夹心法对65例NS及48名正常对照组血浆的sEPCR及sTM进行检测，同步检测各组血浆D-聚体（D-Di）的水平。结果NS组患者血浆sEPCR，sTM及D-Di较正常对照组显著升高（P〈0．05）。其中，膜性肾病组血浆sEPCRJk平比微小病变组及系膜增生组高，差异有统计学意义（P〈0．05）。而sTM及D．Di各病理组之间无显著性差异（P〉0．05）。结论sEPCR及sTM参与NS高凝状态，可作为评估Ns高凝状态的新指标。
Objective To compare the levels of plasma soluble EPCR（sEPCR） and soluble TM（sTM） in patients with primary nephrotic syndrome and in normal control group,and to explore the significance of sEPCR and sTM in patients with primary nephrotic syndrome.Methods 65 NS patients were divided into the minimal change disease（MCD）,membranous nephropathy（MN）,mesangial proliferative glomerulonephritis（MsPGN）.48 cases of healthy controls were also enrolled.Plasma sEPCR and sTM were measured by the enzyme-linked immunosorbent assay（ELISA）;D-dimer were measured in all groups too.Results The levels of plasma sEPCR, sTM and D-dimer in patients with primary nephrotic syndrome were significantly higher than that of controls（P 〈 0.05）. The levels of sEPCR in membranous nephropathy showed statistic differences with mesangial proliferative glomerulonephritis and minimal change nephritis（P 〈 0.05）,while there were no significant differences between all pathologly groups of sTM and D-dimer（P 〉 0.05）.Conclusions The results suggest that sEPCR and sTM may play a role in the pathogenesis of hypercoagulabale state in PNS.The levels of sEPCR and sTM may be a new marker with NS in hypercoagulable state.
出处
《中国血液流变学杂志》
CAS
2011年第4期720-722,共3页
Chinese Journal of Hemorheology
基金
张家港市科技支撑项目（ZKS1014）
关键词
可溶性内皮细胞蛋白C受体
血栓调节蛋白
肾病综合征
soluble endothelial cell protein C receptor
soluble thrombomod.ulin
nephrotic syndrome
