摘要
目的分析盐酸米诺环素软膏辅助治疗慢性牙周炎的临床疗效。方法将40例患慢性牙周炎患者每人选4颗患牙，共160颗，牙周袋深度〉4mm同时探诊出血。将这些患者完全随机分为2组，每组20例80颗患牙。实验组患牙行牙周基础治疗，并在牙周袋内置盐酸米诺环素软膏；对照组仅作牙周基础治疗。观察2组患牙的菌斑指数和牙龈指数的变化，并将牙周袋深度，牙龈出血指数（BI）的指标比较并分析。结果盐酸米诺环素软膏配合牙周基础治疗的实验组在1周和4周时，探诊深度、出血指数低于对照组[1周时分别为（435±0．95）nlln比（5．08±n90）mm、（1．59±0．21）比（2．24±0．23），4周时分别为（2．65±0．41）mm比（4．99±0．55）mm、（0．40±0．08）比（1．54±0．22）]。结论慢性牙周炎在基础治疗上，龈下局部应用米诺环素可取得较好的疗效。
Objective To analyze the clinical effect of minocycline hydrochloride ointment as adjunctive treatment to adult periodontitis. Methods A total of 160 teeth with chronic periodontitis in 40 patients（ four teeth per patient） were selected, with probing depth （PD） 〉4 mm, bleeding and probing （BOP） positive in all cases. 160 teeth were divided randomly into two groups with 80 teeth or 20 patients in each group. The minocycline hydrochloride ointments was applied in the periodontal pockets purposely to the patients in experimental group, whereas the patients in control group only received regular initial periodontal treatment. The differences of two groups＇ teeth in plaque index （PLI） and gingival index （GI） was observed, and the probing depth （PD） and bleeding index （BI） were compared and analyzed. Results It was discovered that, after one and four weeks＇ treatment, the PD and BI in experimental group , to which the minoeycline hydrochloride ointment adjunctive treatment was given, were lowered [ 1 week （4. 35± 0. 95 ） mm vs （ 5.08 ± 0. 90 ） mm, （ 1.59± 0. 21 ） vs （ 2. 24 ± 0. 23 ） ; four weeks （ 2. 65± 0. 4 ） mm vs （4. 99± 0. 55 ） rn, （0. 40±0. 08 ） vs （ 1.54 ± 0. 22 ） ] P 〈 0. 05 ）, compared with those in control group. Conclusion Local delivery of minocycline hydrochloride on the subgingival tends to obtain optimistic curative effect on adult initial periodontal therapy.
出处
《中国医药》
2012年第2期221-222,共2页
China Medicine
关键词
牙周炎
盐酸米诺环素
龈上洁治术
龈下刮治术(牙周基础治疗)
Periodontitis
Minocycline hydrochloride
Supragingival scaling
Subgingival scaling（in-itial periodontal therapy）
