摘要
目的 探讨检测肝癌及肝硬化患者血脂及脂蛋白水平的临床意义。方法 肝病患者６０例，乙肝后肝硬化患者１２６例，健康对照组４０例，空腹１２小时后，收集其清晨静脉血２ｍｌ，采用ＨＩＴＡ－ＣＨＩ－７１５０型全自动生化分析仪，分别测定血清ＴＣ、ＴＣ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ水平。结果 肝癌、肝硬化患者的以上各项指标水平均效对照组显著下降（ｐ＜０．０１），肝癌患者的ＴＣ、ＨＤＬ－ Ｃ水平较肝硬化患者显著下降（ｐ＜０．０１）；肝硬化患者按肝功能Ｃｈｉｌｄ分级，各级均较对照组显著下降（ｐ＜０．０１），其中ＴＣ、ＨＤＬ－Ｃ水平在肝功能Ｃｈｉｌｄ Ｃ级组较Ｃｈｉｌｄ Ｂ级及ＣｈｉｌｄＡ级组下降更显著（ｐ＜ ０．０１）。肝硬化饮酒组与不饮酒组的血清ＴＣ、ＨＤＬ－Ｃ水平差异无显著意义（Ｐ＞０．０５），但均较对照组显著下降（Ｐ＜０．０１）。另外，ＴＣ、ＨＤＩ－ Ｃ水平下降的肝癌患者的６个月生存率明显低于其水平正常者（Ｐ＜０．０１）。结论 肝癌及肝硬化患者存在血清ＴＣ、ＴＧ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ水平的下降，其中ＴＣ、ＨＤＬ－Ｃ可以较准确反映肝硬化患者肝细胞受损的严重程度，可作为判断其病情及预后的辅助手段。长期饮酒者若出现ＴＣ。
Objective To explore the clinical significance of determination of blood lipid and lipoprotein in pa- tients with cancer of the liver and cirrhosis.Methods 60 patients with cancer of the liver, 126 patients with hepati- tis B-cirrhosis, 40 healthful persons as control group, on an empty stomach 12 hours latter, the vein blob 2ml were collected in the morming, through type HITA-CHI-7150 automatic biochemical analysis machine, checked the levels of TC, TC, HDL-C, HDL-C of serum separately. Results All levels above mentionel in patients with cancer of the liver and cirrhosis were much lower than control group (P <0.01). The levels of TC.HDL-C in patients with cancer of the liver were much lower than those patients with cirrhosis. According to the Child-class degree of liver functions in patients with cirrhosis, the levels of each degree were much lower than controls (P < 0.01), the levels of TC, HDL-C in Child C were much lower than Child B and Child A (P<0.0l). The levels of TC, HDL- C Of serum had no much difference between patients with cirrhosis drinking alcohol and not drinking (P > 0.05), but both were lower than controls. Moreover, the 6 months alive rates in patients with cancer of the liver whose levels of TG. HDL-C falled down were much lower those of normal levels(P <0.01). Conclusion The levels of TC, TG, HDI-C, HDL-C in serum falled down in patients with cancer of the liver and cirrhosis. The lev- els of TC, HDL-C may indicate the damage degree of liver cells in patients with cirrhosis exactly, and may regard as supplementary methods to decide the patients condition and prognosis.
出处
《贵州医药》
CAS
2000年第3期138-140,共3页
Guizhou Medical Journal
关键词
血脂
脂蛋白
肝癌
肝硬化
检测
Blood lipid
Lipoprotein
The liver cancer
Cirrhosis
