摘要
目的:通过分析柳州市妇幼保健院2010年6月-2011年6月女性泌尿生殖道支原体感染状况及耐药性变迁,指导临床合理用药。方法:采用微量肉汤稀释法对支原体进行药物敏感性试验。结果:2436例患者检出率为40.0%(975/2436),其中解脲支原体(Uu)阳性821例(33.7%),人型支原体(Mh)阳性24例(1.0%),Uu+Mh阳性130例(5.3%)。药敏结果显示,Uu对交沙霉素、克拉霉素、强力霉素、美满霉素、阿奇霉素较敏感,Mh对美满霉素、交沙霉素、强力霉素、甲砜霉素较敏感,Uu+Mh对美满霉素、交沙霉素、强力霉素较敏感。Uu、Uu+Mh、Mh对抗生素的耐药种数不一致。结论:治疗支原体感染应选择美满霉素、交沙霉素、强力霉素等敏感性高的药物及药敏试验显示敏感的药物,喹诺酮类药耐药率高,应引起临床重视。
OBJECTIVE： To analyze the infection and drug resistance of mycoplasma among female patients in our hospital during Jun. 2010-Jun. 2011 to provide guidance for reasonable use of drugs. METHODS： Micro-broth dilution method was used for monitoring the drug-sensitivity of mycoplasma. RESULTS： Of the total 2 436 cases, the positive rate was 40.0% （975/2 436）, among which 821 cases were Ureaplasma urealyticum （Uu） positive （33.7%）, 24 cases were Mycoplasma hominis （Mh） positive （1.0%）, 130 cases were both Uu＋Mh positive （5.3%）. The sensitive drugs for Uu were josamycin, clarithromycin, deoxytetracy- cline, minocycline and azithromycin. The sensitive drugs for Mh were minocycline, josamycin, deoxytetracycline, thiamphenicol. Minocycline, josamycin, deoxytetracycline were sensitive to Uu＋Mh. The number of drug resistant to Uu, MH, Uu＋ Mh was not consistent. CONCLUSION： We should choose antibiotics such as minocycline, josamycin, deoxytetracycline to which the patho- gens are sensitive in the treatment of mycoplasma infection. Mycoplasma shows a high resistance to quinolones, which should be paid high attention in clinical practice.
出处
《中国药房》
CAS
CSCD
2012年第10期903-905,共3页
China Pharmacy
关键词
泌尿生殖道
解脲支原体
人型支原体
女性
耐药性
Urogenitial tract
Ureaplasma urealyticum
Mycoplasma hominis
Female
Drug resistance
