摘要
目的探讨胰腺实性-假乳头状肿瘤(solid-pseudopapillary tumor of pancreas,SPTP)的临床病理学特点、诊断和鉴别诊断、治疗及其预后。方法对8例SPTP患者的临床、病理学特点及免疫组化结果进行研究,并复习相关文献。结果 8例均为女性,年龄19～38岁,平均28岁。肿块直径3～15 cm。镜下肿瘤由乳头区和囊实区混合组成,瘤细胞围绕纤维血管轴心形成特征性假乳头结构。免疫表型:CK(3/8)、vimentin(8/8)、NSE(8/8)、CD56(8/8)、ER(0/8)、PR(5/8)、α-AT(8/8)、CgA(1/8)、Syn(8/8)、E-cadherin(0/8)、β-连环蛋白(8/8)和cyclinD1的核阳性率均大于40%。随访6例患者17～131个月,均无肿瘤复发及转移,并存活至今。结论 SPTP是一种好发于年轻女性,具有低度恶性潜能的少见胰腺肿瘤,其病理形态特征和免疫组化标记对SPTP的诊断和鉴别诊断具有重要价值。
Purpose To investigate the clinicalpathologic features,diagnosis,differential diagnosis,therapy and prognosis of solid-pseudopapillary tumor of pancreas（SPTP）.Methods The clinical history,histopathological features and immunohistochemical characteristics were analyzed in 8 cases of SPTP,and related literature were reviewed.Results There were 8 female patients,aged from 19~38 years（mean 28）.The sizes of tumors were from 3.5~15 cm.Histologically,they were composed of papillary and microcystic solid structures.Pseudopapilla with a fibro-vascular core was remarkable.Immunohistochemically,the tumors expressed CK（3/8）,vimentin（8/8）,NSE（8/8）,CD56（8/8）,ER（0/8）,PR（5/8）,α-AT（8/8）,CgA（1/8）,Syn（8/8）,E-cadherin（0/8）,and β-cantenin（8/8）.Positive rates of cyclinD1 were all more than 40% in tumor cells.All the patients were followed up for a period of 17~131 months,and they were all alive,had no recurrence and metastasis.Conclusions SPTP is a distinct clinicopathologic entity preferentially in young adult female patients,with low malignant potential.Pathological morphology and immunohistochemistry are very important in the diagnosis and differential diagnosis of SPTP.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2012年第2期147-150,153,共5页
Chinese Journal of Clinical and Experimental Pathology
