摘要
目的:探讨胰腺实性-假乳头状瘤(SPT)的临床病理、免疫组化特征及鉴别诊断。方法:对3例胰腺SPT进行临床病理学分析及免疫组化研究,并作相关文献复习。结果:3例均为女性,年龄11～41岁,平均27.6岁;肿瘤直径平均11.8cm(4.5～13cm)。组织学:单形性肿瘤细胞构成实性及假乳头结构,常伴有出血,间质有不同程度的硬化。免疫组化3例Vim、NSE均阳性,2例a-ACT、Syn阳性,2例CK灶性阳性;CgA、S-100、EMA均阴性。结论:SPT是一种少见的低度恶性肿瘤,其诊断和鉴别诊断主要依据组织学特征。约5%～15%的SFT具有恶性的生物学行为,表现为局部复发或远处转移,其组织构象并不能完全预测其预后,患者术后长期随访是必要的。
Objective：To study the clinicopathologic features and differential diagnosis of solid-pseudopapillary tumor of the pancreas （SPT）.Metheds：Three cases of SPT were analyzed by means of clinicopathology and immunohistochemistry, and the related literature was reviewed. Results：All the patients were females,ll～41 years in age （mean 27. 6 years）;the mean diameter of the tumors was 11.8 cm （rang 4.5～13 cm ） , Histologically,the tumors were composed of monomorphous cells forming solid and pseudopapillary structure ,frequently with haemorrhagic changs and variable stromal sclerosis. Immunohistochemistry,all cases expressed Vim and NSE,2 cases expressed Syn and a-ACT,2 cases expressed CK,but all cases were negative for CgA,S-100 and EMA, Conclusions：SPT of the pancreas is a rare tumor with low malignant potential. The diagnosis and differential diagnosis of the SPT mainly rely on histopathologic characteristics. About 5%～15% SPT have malignant behaviour. The behaviour of SPT is unpredictable ,which requires careful ,long-term follow-up.
出处
《中国误诊学杂志》
CAS
2005年第14期2606-2608,共3页
Chinese Journal of Misdiagnostics
