摘要
目的 探讨乳腺肿瘤超声弹性成像评分同肌成纤维细胞分布的相关性以及对肿瘤良恶性诊断的临床意义.方法 将315例患有乳腺肿块的患者以病理结果为金标准,将其分为良性组及恶性组,应用免疫组织化学法,检测乳腺间质细胞CD34和平滑肌肌动蛋白SMA在两组中的表达情况,判断肌成纤维细胞在乳腺病灶中的分布特征,联合超声弹性成像技术评价乳腺病灶的弹性成像评分与肌成纤维细胞分布的关联性.结果 CD34和α-SMA在良性和恶性乳腺肿瘤患者中表达差异有统计学意义（P＜0.05）：在恶性肿瘤患者中CD34表达水平较低,而α-SMA的表达水平较高；在良性肿瘤患者中相反.CD34在肿瘤内的表达与弹性成像的评分呈负相关（P＜0.05）；α-SMA在肿瘤内的表达与弹性成像的评分高低成正相关性（P ＜0.05）.结论 超声弹性成像可在一定程度上代表肌成纤维细胞在乳腺肿块内的分布特征.
Objective To investigate the correlation and clinical diagnosis significance between ultrasound elastography and the distribution of myofibroblast in breast tumor.To assess the value of ultrasonic elastography and myofibroblast in the diagnosis of breast cancers.Methods Three-hundred and fifteen patients recruited from May 2009 to November 2010 were divided into benign group and malignant group according to postoperative pathological diagnosis results considered as gold standard.The clinical value of the score of ultrasonic elastography was evaluated.The expression levels of CD34 and α-SMA protein in breast tissues were examined by immunohistochemistry.Results The difference was statistically significant for the expression level of CD34 and α-SMA between malignant breast tumor patients compared with benign （ P 〈0.05）.The expression level of CD34 was lower,but α-SMA was higher in the patients of breast cancer compared with benign tumor.However,the expression level of CD34 and α-SMA was just the opposite in the patients of benign tumor.The expression level of CD34 was the negative correlation with the elastography score （ P 〈0.05） in the breast tumor,but α SMA just the opposite situation.Conclusions The score of ultrasound elastography can represent MFS distribution characteristics in breast tumors in the result that α-SMA ＋/CD34- can determine the existence of myofibroblast.
出处
《中华超声影像学杂志》
CSCD
北大核心
2012年第2期138-141,共4页
Chinese Journal of Ultrasonography
基金
国家自然科学基金资助项目（30860080）
