摘要
目的:探讨银杏达莫注射液联合甲钴胺治疗糖尿病周围神经病变的临床疗效。方法:选择2009年6月～2011年5月住院或门诊治疗确诊的糖尿病周围神经病变患者92例作为研究对象,随机将其分为观察组和对照组各46例。两组患者入组前所采用的糖尿病饮食、运动及药物治疗方案不变,并根据血糖水平酌情调整降糖药物剂量;对照组加用甲钴胺0.5 mg肌肉注射,1次/d;观察组在对照组治疗基础上应用银杏达莫注射液30 ml加入生理盐水250 ml中静脉滴注,1次/d。两组患者均连续应用4周评价疗效。结果 :观察组总有效率为91.30%,对照组总有效率为76.09%,两组比较差异有统计学意义(P<0.05)。两组糖尿病周围神经病变患者治疗前后腓神经传导速度比较差异有统计学意义(P<0.05或P<0.01);两组患者治疗后,观察组腓神经传导速度提高优于对照组,两组比较差异有统计学意义(P<0.05)。结论:银杏达莫注射液与甲钴胺联合治疗糖尿病周围神经病变,可以通过不同的作用途径起到叠加和互补的作用,临床症状、体征及神经传导速度均显著改善,且安全性大,值得临床推广应用。
Objective： To explore the clinical effect of Ginkgo Leaf Extract and Dipyridamole Injection combined with Methylcobalamin on diabetic peripheral neuropathy.Methods： 92 patients with definite diabetic peripheral neuropathy from June 2009 to May 2011 in our hospital or ambulatory were selected as the subjects of this study and randomly allocated into two groups including observation group and control group,each 46 cases.Before carrying out this study,the dosage of drug was regulated according to blood sugar level,and with regulation of the diabetic diet,exercise and treatment prescription.In control group,an additional treatment was Methylcobalamin following intramuscular injection with the dose of 0.5 mg performed once a day.In observation group,the corresponding treatment based on the control group was the Ginkgo Leaf Extract and Dipyridamole Injection with the dose of 30 ml and sodium chloride with the dose of 250 ml performed once a day.All patients were received the treatment as described above for four weeks to assess the effectiveness.Results： The total effective rates were 91.30% in observation group and 76.09% in control group respectively,and there was a significant difference between them（P0.05）.There were significant differences for nervus peroneus conduction velocity between two kinds of circumstance including pre-treatment and post-treatment in two groups（P0.05 or P0.01）.After treatment,the nerus peroneus conduction velocity in observation group surpassed that in the control group with statistical significance（P0.05）.Conclusion： The combination between Ginkgo Leaf Extract and Dipyridamole Injection and Methylcobalamin exerts complementary effects through different pathways and can improve clinical symptom,physical sign and nerve conduction velocity with preferable security,and it is worthy to be generalized.
出处
《中国医药导报》
CAS
2012年第1期30-31,36,共3页
China Medical Herald
关键词
糖尿病周围神经病变
银杏达莫
甲钴胺
腓神经传导速度
疗效
Diabetic peripheral neuropathy
Ginkgo Leaf Extract and Dipyridamole
Methylcobalamin
Nerus peroneus conduction velocity
Therapeutic effect
