摘要
目的 研究半乳糖凝集素-3（Galectin-3）与垂体腺瘤侵袭性的关系.方法 用免疫组织化学技术S-P法检测Galectin-3在63例垂体腺瘤的表达,并将38例PRL腺瘤分为侵袭组和非侵袭组,分析两组之间的表达差异.结果 （1）Galectin-3在38例PRL腺瘤中有28例表达（73.68%）,10例ACTH腺瘤中有4例表达（40.00%）,其他类型的垂体腺瘤均未见表达,在正常垂体组织无表达.（2）PRL腺瘤侵袭组与非侵袭组的阳性表达率为92.0%（23/25）和38.46%（5/13）,两组之间差异有统计学意义（P〈0.01）.结论 Galectin-3在不同类型垂体腺瘤有不同的表达,Galectin-3的表达与PRL腺瘤的侵袭性密切相关.
Objective To study the expression of galectin - 3 in pituitary adenoma and investigate the relationship between its expression and invasiveness. Methods The expression Of galactin - 3 of 63 pituitary adenoma were examined by streptavidin/ peroxidase （S -P）immunohistochemical technique, and the 38 cases of prolactinoma were divided into the invasive and noninvasive group. Results （ 1 ） Galectin - 3 was expressed in 28 of 38 （73, 68% ） prolaetinoma, and 4 of 10 ACTH adenoma, but not expressed in other type of adenoma, Galectin - 3 is negative in normal pituitary. （2） The positive rate of galectin - 3 expression in invasive prolactinoma and non -invasive group was 92% （23/25）, 38. 46% （5/13） respectively. Significant difference was found between the two groups （ P 〈 0. 01 ）. Conclusions There is a differential expression of galectin - 3 in pituitary adenoma. The expression Of galectin - 3 in prolactinoma is closely related to its invasiveness.
出处
《浙江临床医学》
2012年第1期1-3,共3页
Zhejiang Clinical Medical Journal
