摘要
目的调查泌尿系统感染病原菌的临床分布及对抗菌药物的耐药性,为临床合理选用抗菌药物、控制医院感染提供依据。方法收集2010年1-12月医院住院及门诊泌尿系统感染患者尿液标本中分离出的466株病原菌进行鉴定和体外药物敏感试验。结果泌尿系统感染以革兰阴性杆菌为主,占75.11%,其中以大肠埃希菌最常见,其次为肺炎克雷伯菌、奇异变形菌,分别占48.07%、7.72%、7.30%,革兰阳性球菌占20.17%,以肠球菌属为主,其中粪肠球菌占9.01%,屎肠球菌占6.87%,真菌仅占4.72%,以白色假丝酵母菌为主;革兰阴性杆菌对碳青霉烯类抗菌药物、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦以及氨基糖苷类抗菌药物具有较高敏感性;革兰阳性球菌对利奈唑胺、万古霉素、替考拉宁、呋喃妥因敏感性好。结论重视尿路感染病原菌耐药性检测,对控制医院感染、合理使用抗菌药物十分重要。
OBJECTIVE To determine distribution and resistance characteristics of pathogens so as to provide diagnostic and treatment evidence for clinic urinary infections.METHODS A total of 466 pathogenic strains were isolated from urine samples of patients with urinary system infection from Jan.2010 to Oct.2010.Strain identification and the drug resistance testing were performed.RESULTS Escherichia coli ranked top one（48.07%） in urinary system infection and followed by Enterococcus faecalis（9.01%）,Klebsiella pneumoniae（7.72%）,Proteus mirabilis（7.30%）,E.faecium（6.87%）.In these isolated pathogenic bacteria,gram-negative bacteria were susceptible to carbapenems,cefperazone/sulbactam,piperacillin/tazobactam and aminoglycosides.Gram-positive bacteria were susceptible to linezolid,vancomycin,teicoplanin and nitrofurantoin.CONCLUSIONS It is important to control nosocomial urinary infection and select antibiotics correctly.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第4期845-847,共3页
Chinese Journal of Nosocomiology
关键词
泌尿系统感染
病原菌
耐药性
Urinary infection
Pathogens
Drug resistance
