摘要
目的探讨长期饮酒伴幽门螺杆菌感染对胃黏膜组织是否存在"二次打击现象"及胃黏膜病理学改变与血液和胃液中的PGE_2和EGF的关系。方法对2007年1月～2010年12月符合条件的120例幽门螺杆菌感染和/或长期饮酒患者进行内镜下胃黏膜活检组织病理学研究,并采用ELISA法检测血清及胃液EGF和PCE_2的水平。结果 (1)两组患者的年龄和饮酒年限比较无统计学差异(P>0.05);(2)长期饮酒伴幽门螺杆菌阳性组患者炎症活动分级明显较单纯长期饮酒组患者更严重,经统计学处理有显著差异(P=0.01);(3)长期饮酒伴幽门螺杆菌阳性组患者萎缩程度分级、肠化分级和不典型增生分级较单纯长期饮酒组患者明显,经统计学处理有差异(P=0.04);(4)长期饮酒伴幽门螺杆菌阳性组患者血清及胃液EGF浓度均明显较单纯饮酒组升高,经统计学处理有显著差异(血清及胃液P=0.00);(5)长期饮酒伴幽门螺杆菌阳性组患者血清PGE_2明显较单纯饮酒组患者升高,经统计学处理有非常明显统计学意义(P=0.00),但两组患者胃液中PGE_2对比却无明显统计学差异(P=0.61)。结论幽门螺杆菌感染同时长期饮酒对胃黏膜组织损害更明显,存在"二次打击现象",EGF和PGE_2共同参与二次打击,造成胃黏膜过度增生,存在矫枉过正现象,这种矫枉过正也可能是长期饮酒合并幽门螺杆菌感染患者容易发生消化道肿瘤的重要机制之一。
Objective To explore if＇ the phenomenon of Second hit＇ exists in the patients with long-term alcohol consumption accompanied by helicobacter pylori infection for gastric mucosa tissues as well as the relation between pathological change of gastric mucosa tissues and prostaglandin E2 （ PGE2 ） and epidermal growth factors（EGF） in serum and gastric juice. Method A study of gastric mucosa acquired by gastroscope was conducted in 120 consecutive patients with helicobacter pylori and/or long-term alcohol consumption from January 2007 to December 2010. EGF and PGE2 in serum and gastric juice were measured by ELISA. Results （ 1 ） There were no significant differences in the two groups between the age and drinking years （ P 〉 0.05 ）. （2） The inflammatory activity stage of in patients with long-term alcohol consumption accompanied by helicobacter pylori was significantly more serious than that of patients only with longerm alcohol consumption（P = 0.01 ）. （3） The classification of atrophy, intestinal metaplasia and dysplasia of gastric mucosa in patients with longterm alcohol consumption accompanied by helicobacter pylori was significantly more serions than that of patiens only with long-term alcohol consumption（ P = 0.04. （4）Compared with the only long-term alcohol consumption group,the concentration of EGF in serum and gastric juice was significantly higher in the long-term alcohol consumption with helicobacter pylori-positive group （ P = 0.00 in serum and gastric juice）. （5） The serum PGE2 in the long-term alcohol consumption with helicobacter pylori-positive group was significantly higher than that in only long-term alcohol consumption group （ P = 0.00 ） ; but there was no significant difference in the PGE2 of gastric juice between the two groups （P = 0.15 ）. Conclusions Because of the more obvious damage to gastric mucosa in the patients with long-term alcohol consumption with helicobacter pylori infection, ＇ the phenomenon of second bit＇ was confirmed. EGF wa
出处
《现代诊断与治疗》
CAS
2012年第1期1-4,共4页
Modern Diagnosis and Treatment
基金
山东省干部保健局资助课题,编号:2007BZ24
关键词
幽门螺杆菌
胃黏膜组织
前列腺素E2
表皮生长因子
Helicobacter pylori
Gastric mucosa tissues
Prostaglandin E2
Epidermal growth factors
