摘要
以邻氟溴苄为起始原料制得的格式试剂与环丙基氰反应,再经溴代、缩合、乙酰化和成盐反应制得抗血栓药物盐酸普拉格雷,总收率18.0%,其结构经1H NMR,MS和IR确证。
Prasugrel hydrochloride in overall yield of 18.0% was synthesized by the reaction of cyclopropyl cyanide with Grignard reagent of 2-fluorobenzyl bromide,then by a four-step reaction of brominetion,condensation,acetylation and salification.The structure was characterized by 1H NMR,MS and IR.
出处
《合成化学》
CAS
CSCD
北大核心
2012年第1期125-127,共3页
Chinese Journal of Synthetic Chemistry
关键词
盐酸普拉格雷
抗血栓药
药物合成
工艺改进
Prasugrel hydrochloride
antithrombotic drug
drug synthesis
process improvement
