摘要
目的观察自拟化浊保源汤治疗慢性肾功能衰竭的临床疗效。方法将中医辨证符合脾肾阳虚、浊毒瘀阻型的90例慢肾衰患者按就诊日期的单双号随机分为两组，对照组40例采用西医常规治疗，包括低盐低蛋白饮食，纠正酸碱失衡与电解质紊乱，纠正贫血，补充氨基酸，控制血糖、血压等；治疗组50例在对照组治疗基础上加用自拟化浊保源汤。观察两组患者治疗前后证候积分、血肌酐（Scr）、尿素氮（BUN）、内生肌酐清除率（Ccr）；血红蛋白（Hb）；天门冬酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）；总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C），等指标的变化。结果治疗后治疗组总有效率为88．0％，对照组为67．5％，两组总有效率比较，差异有统计学意义（P=0．012）。治疗组治疗后Scr（292．95±85．95）]μmol／L、BUN（22．69±9．84．）mmol／L、Ccr（22．69±9．84）ml／min、CH（6．23±0．57）mmol／L、TG（1．70±0．22）mmol／L、HDL-C（1．45±0．04）mmol／L、LDL-C（3．30±0．60）mmol／L均得到改善，与同组治疗前比较，差异均有统计学意义（P〈0．05或0．01）。与对照组治疗后[Scr（336．63±90．77）gmol／L、BUN（10．47±2．71）mmol／L、Ccr（19．47±6．71）ml／min、CH（7．21±0．62）mmol／L、TG（2．30±0．27）mmol／L、HDL-C（0．87±0．05）mmol／L、LDL-C（5．60±0．70）mmol／L]比较，差异均有统计学意义（P均〈0．05）。结论自拟化浊保源汤治疗慢肾衰安全有效。
Objective To observe the effect of treating chronic renal failure with self-made Huazhuo Baoyuan decoction. Methods 90 patients of chronic renal failure belonging to spleen and kidney yang deficiency and turbid toxic obstruction type diagnosed by TCM syndrome differentiation were randomly divided into a treatment group and a control group according to the date of reception. 40 cases in the control group were treated with conventional western medicine, which were low-salt high-quality low-protein diet; to correct acid-base balance and electrolyte imbalance; to correct anemia; adding amino acids; to control blood sugar in patients with history of diabetes; to control blood pressure in patients with hypertension. 50 patients in the treatment group were additionally treated with self-made Huazhuo Baoyuan decoction on the basis of the control group. Such indexes as symptom score, serum creatinine （Scr）, blood urea nitrogen （BUN）, endogenous creatinine clearance rate （Ccr）, hemoglobin （Hb）, liver function： aspartate aminotransferase （AST）, alanine aminotransferase （ALT） ; lipids： total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol （LDL-C） were observed before and after the treatment. Results After treatment, total effective rate was 88.0% and 67.5% in the treatment group and the control group respectively, the difference was statistically significant （P= 0.012） . The value of Scr （292.95___ 85.95） μmol/L, BUN （22.69±9.84） mmol/L, Ccr （22.69±9.84） ml/min, CH （6.23 ±0.57） mmol/L, TG （1.70±0.22） mmol/L, HDL-C （1.45 ± 0.04） mmol/L, LDL-C （3.30 ± 0.60） mmol/L showed significant difference after the treatment than before in the treatment group （P〈0.05 or P〈 0.01）. Compared with the control group of after treatment[Scr（336.63 ± 90.77）μmol/L, BUN（10.47 ± 2.71） retool/L, Ccr（19.47 ±6.71） ml/min, CH （7.21 ± 0.62） retool/L, TG （2.30 ± 0.27） mmol/
出处
《国际中医中药杂志》
2012年第2期113-115,共3页
International Journal of Traditional Chinese Medicine
关键词
中医药治疗
肾功能衰竭
慢性
Traditional Chinese medicine
Renal failure
Chronic
