摘要
目的探讨Yapl蛋白在前列腺癌中的表达及临床病理学意义。方法应用免疫组织化学方法检测Yapl在35例前列腺癌组织和16例良性前列腺增生组织中的表达，用平均吸光度值（积分吸光度／面积，IA／area）代表阳性细胞的表达水平；并探讨Yapl与前列腺癌临床病理参数之间的关系。结果Yapl在良性前列腺增生组的表达水平（IA／area=0．1867±0．0753）明显高于前列腺癌组（IA／area=0．0782-4-0．0614），两组差异有统计学意义（P〈0．01，F=16．942）；Yapl蛋白主要表达在细胞质。Yapl蛋白表达程度与前列腺癌的Gleason评分无明显相关（P〉0．05），但Yapl在Gleason7分组（IA／area=0．0548±0．0441）的表达强度高于Gleason9分组（IA／area=0．1296-4-0．0957）（P〈0．05）。结论前列腺癌中Yapl蛋白低表达可能与前列腺的发生、发展有关。
Objective To study the expression of the yes-associated protein 1 （ Yapl ） in prostate cancer and its clinicopathological significance. Methods We detected the expression of the Yap1 protein in 35 prostate cancer and 16 benign prostate hyperplasia specimens by immunohistochemistry,with mean IA （IA/area） value representing expression level of positive cells. The correlation between the expression level of Yapl and the clinicopathological parameters was analyzed. Results The Yap1 protein was expressed predominantly in the cytoplasm of cells. Yap1 expression was significantly lower in prostate cancer group （IA/area =0. 0782±0. 0614） than in benign prostatic hyperplasia group （IA/area = O. 1867 ±0. 0753）, （P 〈0. 01 ,F = 16. 942）. The expression of Yapl in prostate cancer was not correlated with the Gleason score of prostate cancer （ P 〉 0. 05 ）, however, the expression of Yap1 in low pathological grading （ Gleason 7 ,IA/area =0. 0548 ＋0. 0441 ） was higher than that in high pathological grading （Gieason 9,lA/area = 0. 1296 ±0. 0957 ） ,P 〈 0. 05. Conclusion Yapl expression might be involved in prostate cancer development.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2012年第2期280-281,F0003,F0004,共4页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金资助项目（30801150）
关键词
Yap1
前列腺癌
免疫组织化学
Yes-associated protein 1 （Yapl）
Prostate cancer
Immunohistochemistry
