摘要
癫痫是儿科神经系统疾病中的常见疾病之一,是大脑神经元突发性异常放电,导致短暂的大脑功能障碍的一种慢性脑功能障碍综合征。左乙拉西坦为吡拉西坦的类似物,是一种具有全新抗癫痫作用机制的新型抗癫痫药物。近年来,已广泛用于小儿癫痫包括4岁以下的小儿癫痫的治疗,显示了较好的抗癫痫疗效和安全性。本文就其独特的作用机制、体内药动学特征及国内近年来以左乙拉西坦治疗小儿癫痫的临床研究进行综述。
Epilepsy is one of the common pediatric nervous system diseases.It is a chronic cerebral dysfunction caused by the paroxysmal abnormal discharge of cerebrum neurons.Levetiracetam,as piracetam analogue,is a new antiepileptic drug with total different mechanism.In recent years,it has been widely used in the treatment of epileptic children below 4 years old and shows better antiepileptic effects and safety.This article makes a brief review on levetiracetam′ s unique action mechanism,pharmacokinetic characteristics and clinical researches on the treatment of child epilepsy by levetiracetam.
出处
《现代医药卫生》
2011年第23期3586-3588,共3页
Journal of Modern Medicine & Health
关键词
左乙拉西坦
癫痫
添加治疗
P-糖蛋白
药动学
Levetiracetam
Epilepsy
Add-on therapy
p-glucoprotein
Pharmacokinetics
