摘要
目的探讨左乙拉西坦联合定痫汤治疗小儿难治性癫痫116例临床疗效。方法选取2007年12月～2008年8月门诊或住院确诊为难治性癫痫的患儿116例。联合应用定痫汤和左乙拉西坦治疗患者。随访观察疾病的控制情况。结果116例平均疗程7.4±1.6个月。6个月时疗效评价显示其中87例发作控制,18例显效,3例作用有效,8例无效。12个月时疗效评价98例发作控制,10例显效,8例作用有效。均无严重不良反应。治疗前人均每月发作频率为22.4±4.5次;治疗后人均每月发作频率为6.2±2.1次;治疗前后比较t=16.23;P<0.01,治疗前后发作频率差异有统计学意义。结论左乙拉西坦联合定痫汤治疗小儿难治性癫痫疗效显著,值得进一步推广。
Objective To evaluate the efficacy of levetiracetam combined with Dingxiantang Chinese herbal medicine in treatment of children with refractory epilepsy.Methods A total of 116 children with refractory epilepsy treated from February,2007 to August,2008 in our hospital were treated with levetiracetam combined with Dingxiantang Chinese herbal medicine.Whereafter,Control effect of refractory epilepsy was observated during follow-up.Results Mean course of treatment was 7.4±1.6 months in all cases.By evaluation of efficacy seizure of 87 cases were controlled,18 cases marked efficacy,3 cases efficacy and 8 cases no efficacy 6 months after treatment.Seizure of 98 cases were controlled,10 cases markedly efficacy,8 cases efficacy and 8 cases no efficacy 12 months after treatment.Seizure frequency before treatment was 22.4±4.5 per month and 6 months after treatment was 6.2±2.1 per month(t=16.23,P<0.01).Seizure frequencies after and before treatment had statistical differece.Conclusions Levetiracetam combined with Dingxiantang Chinese herbal is markedly effective for children with refractory epilepsy.
出处
《医学信息（内.外科版）》
2009年第12期1121-1122,共2页
Medical Information Operations Sciences Fascicule
关键词
难治性癫痫
左乙拉西坦
定痫汤
儿童
refractory epilepsy
levetiracetam
Dingxiantang Chinese herbal medicine
children
