摘要
目的探讨膜突蛋白(Moesin)和上皮型钙黏蛋白(E-cadherin)在甲状腺乳头状癌侵袭、转移中的作用。方法采用免疫组织化学SP法,检测81例甲状腺乳头状癌和癌旁正常组织中Moesin和E-cadherin的表达,并将检测结果结合患者的临床资料(性别、年龄、肿瘤大小、局部侵犯、颈淋巴转移、TNM分期)等进行分析。结果甲状腺乳头状癌中的Moesin和E-cadherin的阳性表达率与癌旁正常甲状腺组织之间的差异均有统计学意义(P<0.01)。患者年龄≥45岁、肿瘤侵犯甲状腺被膜外、有颈淋巴结转移、Ⅲ～Ⅳ期甲状腺乳头状癌,Moesin的阳性表达率增高,差异有统计学意义(P<0.01);而E-cadherin的阳性表达率降低,差异有统计学意义(P<0.01)。甲状腺乳头状癌中Moesin与E-cadherin的阳性表达具有相关性(r=-0.494,P<0.01)。结论甲状腺乳头状癌中Moesin的高表达和E-cad-herin的低表达与肿瘤的侵袭和转移有关,两者之间具有协同作用。
Objective To assess the significance of Moesin and E-cadherin in invasion and metastasis of papillary thyroid carcinoma（PTC）. Methods The expressions of Moesin and E-cadherin in 81 cases of PTC and normal thyroid tissues adjacent to cancer were analyzed by immunohistochemieal staining. The correlation between these 2 factors（Moesin, E-cadherin）and clinical features of PTC such as gender, age, tumor size,invasion and lymph node metastasis were studied. Results The rates of immuno-positive staining of Moesin and E-cadherin in PTC were significantly higher than that in the normal thyroid tissues adjacent to cancer （P〈0.01）. The positive expression rates of Moesin in PTC with age≥45 years,local invasion, lymph node metastasis and in stage Ⅲ -Ⅳ was higher than PTC with age〈45 years, without local invasion,without metastasis and in stage I -Ⅱ. There was significant difference, respectively（P〈0 01）. The positive expression rates of E-cadherin in PTC with age45 years,loeal invasion,lymph node metastasis and in stage Ⅲ -Ⅳ was lower than PTC with age 〈45 years, without local invasion,without metastasis and in stage I -Ⅱ. There was significant difference,respectively（P〈0. 01）. There was correla- tion between the expressions of Moesin and E-cadherin in PTC（r = - 0. 494,P〈0.01）. Conclusion The high expressions of Moesin and the low expression of E-eadherin were related to invasion and metastasis of PTC. And the 2 factors have cooperative
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2012年第1期44-47,共4页
Cancer Research on Prevention and Treatment
